ResearchIn-Press PreviewInflammation
Open Access | 10.1172/jci.insight.138385
1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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1Division of Rheumatology, University of Michigan, Ann Arbor, United States of America
2Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, United States of America
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Knight, J.
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Published December 29, 2020 - More info
Ginger is known to have anti-inflammatory and anti-oxidative effects, and has traditionally been used as an herbal supplement in the treatment of various chronic diseases. Here, we report anti-neutrophil properties of 6-gingerol, the most abundant bioactive compound of ginger root, in models of lupus and antiphospholipid syndrome (APS). Specifically, we demonstrate that 6-gingerol attenuates neutrophil extracellular trap (NET) release in response to lupus- and APS-relevant stimuli through a mechanism that at least partially dependent on inhibition of phosphodiesterases. At the same time, administration of 6-gingerol to mice reduces NET release in various models of lupus and APS, while also improving other disease-relevant endpoints such as autoantibody formation and large-vein thrombosis. In summary, this study is the first to demonstrate a protective role for ginger-derived compounds in the context of lupus, and importantly provides a potential mechanism for these effects via phosphodiesterase inhibition and attenuation of neutrophil hyperactivity.