Epithelial IL-33 in chronic airway disease

In this episode, Jennifer Alexander-Brett and colleagues explain that epithelial IL-33 co-secretion with exosomes is blocked by inhibitors of the neutral sphingomyelinase-dependent multivesicular endosome pathway, which reduces type-2 inflammation in airway disease.

TRPV4 channels are essential for protection from lung edema

In this episode, Alexander Dietrich and Christian Schremmer explain how TRPV4 is essential for alveolar epithelial function and protects from ischemia-reperfusion induced lung edema.

Predicting atrial fibrillation after ablation

In this episode, Jasmeet Reyat, Winnie Chua, Larissa Fabritz, and colleagues explain that, building on genomic and experimental findings, low PITX2 in left atrial cardiomyocytes and high BMP10 in plasma predict recurrent AF in patients after ablation.

C5a impairs phagosomal maturation through phosphoproteomic remodeling

C5a disrupts the neutrophil phosphoproteomic response to bacteria, impairing phagosomal maturation and bacterial killing.

TSC–associated cystic kidney disease is prevented in pregnancy

In this episode, Oded Volovelsky and colleagues report that rapamycin or dexamethasone administration in pregnancy to a mouse model of tuberous sclerosis complex disease prevents cystic kidney disease in offspring.