Peptide recognition by T and B cells in rheumatoid arthritis

In this episode, Jane Buckner discusses how citrullinated tenascin-C is an autoantigen that is targeted by autoreactive CD4+ T cells and autoantibodies in patients with rheumatoid arthritis.

Humanized mouse models of MC4R-linked obesity

In this episode, Michel Bouvier explains the present study aimed at testing pharmacological chaperones in humanized MC4R mouses model as potential therapeutic treatment of melanocortin type 4 receptor linked obesity.

Aging and T cells during recovery from influenza pneumonia

The age-related pro-repair function of Treg cells following influenza infection is determined by cell-autonomous mechanisms.

Protection against iatrogenically induced hearing loss

In this episode, Marisa Zallocchi explains how treatment with quinoxaline derivatives protects from aminoglycoside- and cisplatin-hearing loss by NF-kB inhibition.

Epithelial IL-33 in chronic airway disease

In this episode, Jennifer Alexander-Brett and colleagues explain that epithelial IL-33 co-secretion with exosomes is blocked by inhibitors of the neutral sphingomyelinase-dependent multivesicular endosome pathway, which reduces type-2 inflammation in airway disease.