In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor leading to premature parturition through inflammasome-associated and -independent mechanisms.
In this episode, Christopher Willey describes a panel of acquired radiation resistant GBM PDX and identifies potentially targetable transcriptomic (including lncRNA) and kinomic alterations.
In this episode, Peng Yao explains that FAM114A1 modulates cardiac fibrosis by regulating Ang II signaling and pharmacological inhibition of FAM114A1 is a therapeutic strategy for the treatment of heart disease.
In this episode, David Patrick describes a new mechanism responsible for systemic lupus erythematosus (SLE). IsoLGs accumulate in cells of patients with lupus and lupus prone mice. Scavenging of IsoLGs attenuates autoimmunity and hypertension in lupus prone mice. IsoLGs adduct to and inhibit the activity of PU.1. This suppresses the transcription of C1q subunits.
In this episode, Dr. Ramani Ramchandran explains that, in this study, the authors show that cilia on endothelial cells can disassemble under shear stress, and proteins from cilia can be tracked in fluids as a result of the disassembly process.