Quisinostat as a radiosensitizer for the treatment of glioblastoma

In this episode, Costanza Lo Cascio, Artak Tovmasyan, and Shwetal Mehta discuss the identification of a brain-penetrant HDAC inhibitor with radiosensitizing properties for the treatment of glioblastoma.

Sorting nexin 10 and glioblastoma stem cells via protein sorting

In this episode, Ryan Gimple and colleagues explain that glioblastoma stem cells depend on SNX10, an endosomal protein sorting factor, which maintains cancer cell proliferation and stemness through platelet-derived growth factor receptor signaling.

Stabilization of E-cadherin adhesions and metastatic breast cancer

In this episode, Kuppusamy Balamurugan and colleagues explain that COX-2 promotes E-Cadherin complex protein expression, and celecoxib in combination with paclitaxel diminishes cluster circulating tumor cells and established metastases in preclinical breast cancer models.

NLRP3 signaling and preterm labor and birth

In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor leading to premature parturition through inflammasome-associated and -independent mechanisms.

Long noncoding RNAs and targetable kinases and glioblastoma radiation resistance

In this episode, Christopher Willey describes a panel of acquired radiation resistant GBM PDX and identifies potentially targetable transcriptomic (including lncRNA) and kinomic alterations.