In this episode, Jane Buckner discusses how citrullinated tenascin-C is an autoantigen that is targeted by autoreactive CD4+ T cells and autoantibodies in patients with rheumatoid arthritis.
In this episode, Michel Bouvier explains the present study aimed at testing pharmacological chaperones in humanized MC4R mouses model as potential therapeutic treatment of melanocortin type 4 receptor linked obesity.
The age-related pro-repair function of Treg cells following influenza infection is determined by cell-autonomous mechanisms.
In this episode, Marisa Zallocchi explains how treatment with quinoxaline derivatives protects from aminoglycoside- and cisplatin-hearing loss by NF-kB inhibition.
In this episode, Jennifer Alexander-Brett and colleagues explain that epithelial IL-33 co-secretion with exosomes is blocked by inhibitors of the neutral sphingomyelinase-dependent multivesicular endosome pathway, which reduces type-2 inflammation in airway disease.