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Antineutrophil properties of natural gingerols in models of lupus
Ramadan A. Ali, … , Duxin Sun, Jason S. Knight
Ramadan A. Ali, … , Duxin Sun, Jason S. Knight
Published December 29, 2020
Citation Information: JCI Insight. 2021;6(3):e138385. https://doi.org/10.1172/jci.insight.138385.
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Research Article Inflammation

Antineutrophil properties of natural gingerols in models of lupus

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Abstract

Ginger is known to have antiinflammatory and antioxidative effects and has traditionally been used as an herbal supplement in the treatment of various chronic diseases. Here, we report antineutrophil properties of 6-gingerol, the most abundant bioactive compound of ginger root, in models of lupus and antiphospholipid syndrome (APS). Specifically, we demonstrate that 6-gingerol attenuates neutrophil extracellular trap (NET) release in response to lupus- and APS-relevant stimuli through a mechanism that is at least partially dependent on inhibition of phosphodiesterases. At the same time, administration of 6-gingerol to mice reduces NET release in various models of lupus and APS, while also improving other disease-relevant endpoints, such as autoantibody formation and large-vein thrombosis. In summary, this study is the first to our knowledge to demonstrate a protective role for ginger-derived compounds in the context of lupus. Importantly, it provides a potential mechanism for these effects via phosphodiesterase inhibition and attenuation of neutrophil hyperactivity.

Authors

Ramadan A. Ali, Alex A. Gandhi, Lipeng Dai, Julia Weiner, Shanea K. Estes, Srilakshmi Yalavarthi, Kelsey Gockman, Duxin Sun, Jason S. Knight

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Figure 6

6-Gingerol prevents aPL-mediated acceleration of venous thrombosis.

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6-Gingerol prevents aPL-mediated acceleration of venous thrombosis.
Sche...
Schematic of the electrolytic model of venous thrombosis (A). Direct current results in the release of free radicals within the inferior vena cava, which activate endothelial cells and initiate a thrombogenic environment in the presence of constant blood flow. MPO-DNA complexes were measured in serum of mice treated with control IgG or APS IgG in the presence or absence of 6-gingerol (B). Thrombus formation was assessed at 24 hours. Thrombus length (C) and thrombus weight (D) were measured. Representative thrombi (E). **P < 0.01, ***P < 0.001, ****P < 0.0001 by 1-way ANOVA corrected with Dunnett’s test.

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