JCI Insight -- New Articles https://insight.jci.org/current en-us 2026 The American Society for Clinical Investigation JCI Insight http://insight.jci.org/assets/common/jci-only-white-blue-bg.png http://insight.jci.org <![CDATA[Characterizing enteric pathology in MPS IIIA mice suggests disease-specific vulnerability among lysosomal storage disorders]]> https://insight.jci.org/articles/view/202780 info:doi/10.1172/jci.insight.202780 The American Society for Clinical Investigation <![CDATA[Estrogen promotes tumor phenotypes in ER+ and ER– breast cancer through UGDH-GPR30]]> https://insight.jci.org/articles/view/197357 info:doi/10.1172/jci.insight.197357 The American Society for Clinical Investigation <![CDATA[Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation]]> https://insight.jci.org/articles/view/208733 info:doi/10.1172/jci.insight.208733 The American Society for Clinical Investigation <![CDATA[Specificity, frequency, and phenotype of citrullinated-specific T cells vary with disease activity in rheumatoid arthritis]]> https://insight.jci.org/articles/view/202159 info:doi/10.1172/jci.insight.202159 The American Society for Clinical Investigation <![CDATA[Noncoding RNA TY1 reverses fibrosis in systemic sclerosis by attenuating the cGAS/STING pathway]]> https://insight.jci.org/articles/view/197716 info:doi/10.1172/jci.insight.197716 The American Society for Clinical Investigation <![CDATA[A cross-model single-cell atlas reveals conserved involvement of osteopontin in polycystic kidney disease]]> https://insight.jci.org/articles/view/207157 info:doi/10.1172/jci.insight.207157 The American Society for Clinical Investigation <![CDATA[Discovery of CD4+ T cell–recognized B. pertussis antigens that reduce airway colonization]]> https://insight.jci.org/articles/view/199234 info:doi/10.1172/jci.insight.199234 The American Society for Clinical Investigation <![CDATA[Urinary YKL-40 as a diagnostic biomarker for cystinosis]]> https://insight.jci.org/articles/view/206193 info:doi/10.1172/jci.insight.206193 The American Society for Clinical Investigation <![CDATA[Human Y chromosome pan-organ mapping reveals progressive mosaic loss from normal to cancer]]> https://insight.jci.org/articles/view/201996 info:doi/10.1172/jci.insight.201996 The American Society for Clinical Investigation <![CDATA[Spatial multiomics in biomedical research: advances beyond transcriptomics]]> https://insight.jci.org/articles/view/206951 info:doi/10.1172/jci.insight.206951 The American Society for Clinical Investigation <![CDATA[Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease]]> https://insight.jci.org/articles/view/200076 info:doi/10.1172/jci.insight.200076 The American Society for Clinical Investigation <![CDATA[Hypercapnia enhances airway smooth muscle contractility via STIM1-dependent Ca2+ signaling]]> https://insight.jci.org/articles/view/202475 info:doi/10.1172/jci.insight.202475 The American Society for Clinical Investigation <![CDATA[Multiomic analysis identifies T cell subsets and mechanisms of epithelial interaction in idiopathic pulmonary fibrosis]]> https://insight.jci.org/articles/view/203080 info:doi/10.1172/jci.insight.203080 The American Society for Clinical Investigation <![CDATA[IL-27 neutralization with and without antibiotics as an approach to prevent and treat neonatal sepsis]]> https://insight.jci.org/articles/view/204603 info:doi/10.1172/jci.insight.204603 The American Society for Clinical Investigation <![CDATA[Human pericardial macrophages suppress cardiac fibrosis through cystatin C signaling after myocardial infarction]]> https://insight.jci.org/articles/view/202383 info:doi/10.1172/jci.insight.202383 The American Society for Clinical Investigation <![CDATA[Local growth hormone promotes benign prostatic hyperplasia]]> https://insight.jci.org/articles/view/206012 info:doi/10.1172/jci.insight.206012 The American Society for Clinical Investigation <![CDATA[CXCR4 coordinates adhesion, migration, and development of human NK cells]]> https://insight.jci.org/articles/view/206701 info:doi/10.1172/jci.insight.206701 The American Society for Clinical Investigation <![CDATA[Role of CD4+ T cell mannose binding lectin in Schistosoma-induced pulmonary hypertension]]> https://insight.jci.org/articles/view/202919 info:doi/10.1172/jci.insight.202919 The American Society for Clinical Investigation <![CDATA[A familial case of FLAD1 protein deficiency associated with impaired adrenal steroidogenesis]]> https://insight.jci.org/articles/view/198799 info:doi/10.1172/jci.insight.198799 The American Society for Clinical Investigation <![CDATA[α-Ketoglutarate accelerates cutaneous wound healing through modulating the epithelial-fibroblast niche]]> https://insight.jci.org/articles/view/201852 info:doi/10.1172/jci.insight.201852 The American Society for Clinical Investigation <![CDATA[Progressive hypothalamic neuroinflammation in ovariectomized mice parallels aging-related transcriptomic changes in the female human hypothalamus]]> https://insight.jci.org/articles/view/207270 info:doi/10.1172/jci.insight.207270 The American Society for Clinical Investigation <![CDATA[Single-cell RNA sequencing reveals clonally expanded CD4+ tissue-resident memory T cells in histidyl-tRNA synthetase–induced myositis]]> https://insight.jci.org/articles/view/208009 info:doi/10.1172/jci.insight.208009 The American Society for Clinical Investigation <![CDATA[Activation of lung megakaryocyte α7 nAChR exacerbates allergic airway inflammation via IL-33/p38 MAPK signaling]]> https://insight.jci.org/articles/view/202201 info:doi/10.1172/jci.insight.202201 The American Society for Clinical Investigation <![CDATA[Impaired regulation by purinergic signaling axis contributes to CD8+ T cell dysregulation in STAT3 gain of function]]> https://insight.jci.org/articles/view/202959 info:doi/10.1172/jci.insight.202959 The American Society for Clinical Investigation <![CDATA[Genetic background influences developmental airway smooth muscle program and susceptibility to airway hyperresponsiveness in mice]]> https://insight.jci.org/articles/view/200486 info:doi/10.1172/jci.insight.200486 The American Society for Clinical Investigation <![CDATA[Plasma proteins associated with chronic graft-versus-host disease organ involvement]]> https://insight.jci.org/articles/view/209042 info:doi/10.1172/jci.insight.209042 The American Society for Clinical Investigation