Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders
KC Srivastava, T Mustafa - Medical hypotheses, 1992 - Elsevier
One of the features of inflammation is increased oxygenation of arachidonic acid which is
metabolized by two enzymic pathways—the cyclooxygenase (CO) and the 5-lipoxygenase
(5-LO)—leading to the production of prostaglandins and leukotrienes respectively. Amongst
the CO products, PGE 2 and amongst the 5-LO products, LTB 4 are considered important
mediators of inflammation. More than 200 potential drugs ranging from non-steroidal anti-
inflammatory drugs, corticosteroids, gold salts, disease modifying anti-rheumatic drugs …
metabolized by two enzymic pathways—the cyclooxygenase (CO) and the 5-lipoxygenase
(5-LO)—leading to the production of prostaglandins and leukotrienes respectively. Amongst
the CO products, PGE 2 and amongst the 5-LO products, LTB 4 are considered important
mediators of inflammation. More than 200 potential drugs ranging from non-steroidal anti-
inflammatory drugs, corticosteroids, gold salts, disease modifying anti-rheumatic drugs …
