Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger
E Nurtjahja-Tjendraputra, AJ Ammit, BD Roufogalis… - Thrombosis research, 2003 - Elsevier
Background: Based on recent studies, pungent constituents of ginger (Zingiber officinale)
and related substances represent a potential new class of anti-platelet agents. The ability of
20 pungent constituents of ginger and related substances to inhibit arachidonic acid (AA)
induced platelet activation in human whole blood was studied. Methods: Anti-platelet activity
of the compounds was measured in vitro by the Chrono Log whole blood platelet
aggregometer. Molecular hydrophobicity (log P) was measured by reversed-phase high …
and related substances represent a potential new class of anti-platelet agents. The ability of
20 pungent constituents of ginger and related substances to inhibit arachidonic acid (AA)
induced platelet activation in human whole blood was studied. Methods: Anti-platelet activity
of the compounds was measured in vitro by the Chrono Log whole blood platelet
aggregometer. Molecular hydrophobicity (log P) was measured by reversed-phase high …