The Editors encourage authors to familiarize themselves with the information below to ensure that their submissions are handled efficiently and evaluated fairly in accordance with JCI Insight's guidelines and policies.
Revised March 21 2019 | Revision history
Research articles describe new insights into biology and disease. They are descriptions of studies of scientific importance and interest to researchers in the field.
Clinical Medicine articles report new medical therapies, interventions, diagnostic advances, or observational studies in humans that are important to clinical researchers in the field.
Technical Advance articles describe new and important research tools and techniques that could have a wide-ranging impact. They optimally also describe how the technique can be applied to address a specific question relevant to understanding or treating a disease.
Note: The recommended length for JCI Insight submissions is 9,000 words; the maximum allowable length of an accepted manuscript is 12,000 words, including the text of legends, tables, and references.
Manuscripts must be submitted through the JCI family’s submission website. An account is required in order to proceed with submission; authors can register for accounts or access their existing accounts by following the instructions at the-jci.org.
Authors may transfer research manuscripts from the preprint server bioRxiv for submission to JCI Insight. Once the manuscript is transferred, corresponding authors will receive an email message indicating that the draft submission is ready for review and be asked to provide additional information. Required documents are as described below.
In brief, during the online submission process, submitters are asked to state adherence to editorial policies; specify funding sources; upload the manuscript and supporting documents; and enter a cover letter, abstract, author list, and keywords. Additionally, authors may note up to 2 reviewers they wish to exclude and reason(s) for exclusion.
If your manuscript was transferred from the JCI to JCI Insight, you do not need to create a new record for the submission. If you receive an invitation to transfer your submission to JCI Insight, the email will include a link to a web page where you can accept or decline the invitation. Manuscripts are transferred to JCI Insight in the original formatting used for submission to the JCI and are handled by the editor who issued the invitation to transfer.
The invitation to transfer your manuscript to JCI Insight will remain open for 60 days. If you have any questions concerning the transfer process, please contact the JCI Insight staff (email@example.com). Authors who wish to inquire about the suitability of transferring their manuscript from JCI to JCI Insight should contact the editors (firstname.lastname@example.org)
Requests to transfer manuscripts that have been rejected following peer review by other top-tier journals will be considered on a pre-submission basis. Interested authors may submit inquiries to the Editors at email@example.com.
Your inquiry must include the original manuscript, the full decision letter, and reviews from the previous journal, as well as your proposed response to the critiques received. Authors must include a statement in their cover letter declaring that the original decision letter and reviewer comments are unaltered.
In response to a request for external transfer, the Editors may
Note: For manuscripts transferred from the JCI to JCI Insight, all submitted materials will be automatically reassigned to JCI Insight.
JC Insight manuscripts include the following sections (see Requirements specific to Clinical Medicine submissions):
Note: The recommended length for JCI Insight submissions is 9,000 words; the maximum allowable length of an accepted manuscript is 12,000 words, including the text of legends, tables, and references.
For all manuscripts, ensure that:
The manuscript title should be a clear and concise description of the work; we recommend that titles not exceed 15 words including conjunctions. Subtitles, colons, and nonstandard abbreviations are unacceptable.
First and last names of all authors, as well as their affiliations (departments, institutions, and locations) during the period when the work was performed. Assign affiliation footnotes consecutively using superscript numbers (1, 2, 3, etc.). If any author's affiliation has changed since completion of the work, specify the present affiliation and location below the numbered list. Provide the complete name, address, telephone number (including country code, where applicable), and e-mail address of the corresponding author. If the author list includes a consortium/study group as author (e.g., CARDIoGRAM Consortium) without specifying the individuals’ names, list the members of each consortium named and their affiliations in the Supplemental material; add the following sentence to the Acknowledgments section: “See Supplemental Acknowledgments for consortium details.”
Provide a statement consistent with JCI Insight’s conflict of interest policy. If no author has a conflict, include the following: “The authors have declared that no conflict of interest exists.”
The abstract may not contain any primary data or references; all nonstandard abbreviations must be defined.
Provide a paragraph titled “Author contributions” specifying how each author (identified by initials) contributed to the manuscript. Examples include designing research studies, conducting experiments, acquiring data, analyzing data, providing reagents, and writing the manuscript. Multiple contributions may be listed for a single individual, and more than one individual may be associated with a single contribution.
An Acknowledgments paragraph states sources of support in the form of grants, equipment, or drugs. Other appropriate acknowledgments (for example, to other scientists for their help or advice) may also be included.
Authors may submit a graphical abstract, a single image that visually represents the primary findings of an article. Published graphical abstracts appear at the top of the online version of the article. Details are available here.
Authors of accepted manuscripts may provide related supplemental data to be posted online along with the published manuscript. This may include figures, tables, videos, or appendices but excludes large datasets. All Supplemental Data information (except videos) should be combined into a single PDF file. Before submission, carefully review all files; they will not be checked by a copy editor. JCI Insight is not responsible for any errors contained in data supplements.
A detailed conflict of interest policy is available here. All authors are expected to disclose financial relationships, consultancies, stock or equity interests, patent-licensing arrangements, or any other interest of a financial nature, whether or not directly related to the subject material of the study, since it could undermine the objectivity, integrity, or perceived value of the publication.
If samples have been randomly assigned to experimental groups or processing order, a statement specifying the randomization procedure should be included in Methods.
If investigators have been blinded to the sample group allocation during the experiment or analysis of the experimental outcome, a statement describing the level of blinding should be included in Methods.
Authors must provide sufficient details about the sample collection to distinguish between independent biological replicates and technical replicates. Biological replicates represent samples from different sources, while technical replicates represent an assay of a sample from the same source multiple times. The exact number of samples (n) for each figure panel representing multiple experiments must be included in the figure or its legend. For representative experiments, authors must state the number of times this experiment was repeated.
The Methods section should include an adequate description of the experimental procedures to allow researchers in the field to reproduce the work. Authors may include additional methods in the supplemental materials as needed.
Authors must fully describe all statistical tests used during the analysis in the methods, and the statistical test used must also be reported in the relevant figure legend. We encourage authors to describe methods used to assess whether the data met the assumptions of the statistical test utilized (e.g., normal distribution). Authors must specify whether statistical tests are one-sided or two-sided. When making multiple comparisons on a single data set, authors should choose statistical tests that account for multiple groups (such as ANOVA rather than a series of t tests). The statistical analysis should also correct for repeated measures when comparing multiple measurements within subjects. A statement describing inclusion/exclusion criteria must be included in Methods if any samples were excluded from the analysis. Error bars must be defined, either in Methods or in the legends themselves; e.g., “Data represent mean ± SEM.” Variance around the mean and statistical analysis should not be presented if fewer than 3 independent samples are included.
All clinical investigation must have been conducted according to Declaration of Helsinki principles. All human studies must have been approved by the appropriate institutional review board(s), and a specific declaration of such approval must be made in a stand-alone paragraph at the end of the Methods section, including a statement indicating that written informed consent was received from participants prior to inclusion in the study. Participants should be identified by number, not by name. Manuscripts without declaration of ethical approval for experiments will not be reviewed. For manuscripts that include patient photographs, a separate statement must be included, in the Study Approval section of Methods, that written informed consent was provided for pictures appearing in the manuscript.
Authors are encouraged to follow the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines for reporting on animal studies. For animal models, the precise genotype, strain, source, number of backcrosses, sex, and age of animals studied must be provided in the manuscript. All animal studies must have been approved by the appropriate institutional review board(s), and a specific declaration of such approval must be made in a stand-alone paragraph at the end of the Methods section.
Authors must describe the source of all cell lines utilized. Authors are also encouraged to include information regarding authentication of cell lines and testing for mycoplasma contamination.
A description of all antibodies used is included in Methods, providing the source and catalog/clone number for commercial antibodies or a description/reference to a description of the generation of custom antibodies.
Large datasets for gene expression microarrays, SNP arrays, and high-throughput sequencing studies must be deposited in a public repository. Microarray data must be deposited in a MIAME-compliant public database. High-throughput sequencing data must be deposited in a MINSEQE-compliant public database. Provide the relevant accession numbers in the text of the main manuscript. Deposition of other types of large datasets in a public repository is strongly encouraged. Other supporting datasets must be made available to any interested reader on the publication date from the authors directly. Researchers who encounter a persistent refusal by an author of a paper to comply with these guidelines should contact the Editors’ office by e-mail at firstname.lastname@example.org.
Authors must submit original nucleotide or amino acid sequence data to GenBank, the EMBL-EBI database, DNA Databank of Japan (DDBJ), or another appropriate publicly available database in general use in the field that gives free access to researchers from the date of publication.
For any new chemical compound described, the chemical structure must be reported. Authors must also provide adequate data to support assignment of identity and purity of the compounds. For most compounds, chemical identity should be established through spectroscopic analysis. Authors should include adequate experimental and characterization data in Methods or Supplemental Methods. Methods describing the synthesis of new compounds must also be included.
For authors reporting T cell assays and NK cell assays, we recommend including Minimal Information About T cell Assays (MIATA) in Methods, figure legends, or elsewhere as appropriate.
Authors describing new software that they have developed are encouraged to report the source code for software in the Supplemental Methods or include a statement regarding how the software can be obtained.
In accordance with the requirements set forth in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals issued by the International Committee for Medical Journal Editors (ICMJE), we ask that authors provide specific information regarding the ethical treatment of research participants, patient consent, patient privacy, protocols, authorship, and competing interests. A Clinical Medicine submission must include:
JCI Insight recommends that authors check the Equator Network for a list of reporting guidelines for each study type.
A systematic review is a literature review that follows an explicit protocol to systematically identify, appraise, and synthesize the findings of studies that address a similar question. A meta-analysis is a quantitative synthesis of the results of a systematic review.
JCI Insight defines observational studies as those in which the assignment of the medical intervention is not at the discretion of the investigator.
JCI Insight provides the option to publish a PDF of the accepted research paper as an In-Press Preview prior to copyediting and layout. Following provisional acceptance of the manuscript, the corresponding author may select the In-Press Preview option when resubmitting via our submission site. If the author chooses this option, the PDF will be published on the JCI Insight website soon after acceptance, and the paper will be indexed by PubMed; publication of the in-press preview is considered the end of the article's embargo period. This version will be replaced upon finalization of copyediting, layout, and author proofing according to the journal’s regular publication schedule.
All authors associated with the submission are sent an e-mail requesting assignment of copyright to the American Society for Clinical Investigation (ASCI) prior to publication. Authors with Wellcome or related funding should request a CC-BY license, and the ASCI will ensure that these articles are published according to the funding agency's policy. Please see JCI Insight’s License information page for copyright information.
All JCI Insight articles are freely available online at the journal’s website immediately upon publication. Charges (in US$) assessed to authors help support publication of JCI Insight. Authors will be assessed $3650 for publication of articles, and the invoice will be provided along with the publication proofs.
Proofs will be sent to the corresponding author, who will be asked to answer copy editor queries and make any necessary corrections; substantive changes to the text are not permitted. If the corresponding author will be unavailable, JCI Insight staff must be informed of another author responsible for the proof. The proof must be returned within 2 days; late proofs could lead to a delay in publication.
JCI Insight deposits all articles in PubMed Central, and all research is available immediately after publication. Authors of articles published in JCI Insight do not need to submit their accepted articles separately to PubMed Central. This satisfies the NIH Public Access Policy and other similar funder requirements.
JCI Insight is indexed in the following resources:
The Editors recognize that some authors may wish to publicize their work in the lay press. An embargo date and time is established for each article to be published in JCI Insight, and violation of the embargo by authors is considered grounds for withdrawal of the manuscript from publication and/or other measures that the Editors may choose to take. Any specific questions about the embargo policy should be addressed to the Editors at email@example.com.
JCI Insight does not consider research manuscripts that have been posted to a community preprint server to be prior publications.
Newly submitted manuscripts are assigned to an Editor, who will determine whether to send it for external review. The Editor may seek the advice of a member of our consulting editorial board with expertise in the field prior to making this initial decision. The necessary criteria for sending a manuscript for external review are that the work is technically well executed and the findings are of clinical relevance. The studies should include a relevant in vivo model and/or a primary human cell or tissue model. When papers are sent for external review, the choice of reviewers is made by the Editor and may include reviewers suggested by the authors. Requests by authors to exclude two specific potential reviewers will be honored to the greatest extent possible. At least two, and generally three, expert referees are asked to review the manuscript in a timely manner and to assign a priority based on content, quality, and relevance. Authors are informed of the final decision by e-mail, with applicable comments from reviewers and editors included.
ASCI members. Any dues-paying ASCI member who is a corresponding author of a first-round submission to the JCI, and whose dues are current, may designate 3 first-round submissions per calendar year to be guaranteed for external peer review. Submissions using the guaranteed review must fit within the scope of the journal and will be held to the same standard for publication as other manuscripts considered by the Editorial Board. Upon submission of a manuscript, eligible ASCI members who have not yet used this option for the calendar year will receive an e-mail notification that the option is available and must respond within 2 days to elect this option. (Please note that if guaranteed external review is selected for a first-round submission subsequently identified as a revision of a previously submitted manuscript, the guarantee will be removed and become available for use on another submission.)
Reviewer rewards. Frequent reviewers are provided the opportunity to submit a new manuscript, as corresponding author, with a guarantee of external review. The Reviewer Reward is granted in January to reviewers who have completed on-time reviews for at least 3 separate manuscripts within the preceding 18 months. Only 1 reward may be used per calendar year. Submissions using the reward must fit within the scope of the journal and will be held to the same standard for publication as other manuscripts considered by the Editorial Board. Note: ASCI members whose dues are current receive a separate benefit for guaranteed external review and may not earn Reviewer Rewards in addition. More details are available here.
The peer-review process rests on the assumption that an assigned reviewer will treat all manuscripts as privileged information. A reviewer may request advice from another party, subject to the general principle of confidentiality and notification of JCI Insight.
Manuscripts may be accepted with no changes, provisionally accepted pending minor revisions, or rejected. For a rejected manuscript, if the reviewers and editors believe that the paper, if appropriately revised, will achieve a high enough priority to be published in JCI Insight, the authors are invited to submit a revision. All revised manuscripts are carefully reexamined. While acceptance cannot be guaranteed, the editors will make every effort to ensure that revised manuscripts are accepted presuming that the authors are able to address all reviewer criticisms. If the authors of a rejected manuscript believe that a serious scientific error occurred during the review process, they may send a rebuttal explaining why the editors should reconsider the decision (see Contacting JCI Insight). While few rebuttals are successful in reversing the original decision, they are taken seriously, and their handling can take several weeks. If authors of rejected manuscripts are subsequently able to make new advances that go far beyond the original submission, they may consider submitting a substantially revised manuscript for de novo review. The authors should refer to the prior version in their cover letter, particularly to indicate how the present version differs. The Editors will make a determination of whether the work is sufficiently advanced beyond the original submission. Note that de novo submissions are considered as new papers and may be sent to the same or independent referees.
Questions regarding manuscript handling and status should be addressed to firstname.lastname@example.org. To avoid the possibility of misinterpretation and/or errors in communication, information will be given only to the corresponding author.
Questions concerning editorial policies or decisions should be addressed to the Editors at email@example.com.
Authors may submit inquiries to JCI Insight regarding manuscripts of potential suitability. Inquiries must include the manuscript abstract and a statement detailing the reasons why the manuscript might be of interest to the journal’s readership. Decisions on such inquiries are not a substitute for peer review but are intended to provide informal guidance to authors in determining where to submit their research for full peer review.
By submitting a manuscript to the JCI or JCI Insight, the authors agree to subject it to the confidential peer-review process outlined above. However, all manuscripts remain the property of the submitting author(s) unless a decision to accept the manuscript is made and the authors officially assign copyright to the ASCI. Please see JCI Insight's License information page for copyright information.
As of the date of publication, authors will be required to make materials and methods used available to academic researchers for their own use. No exceptions will be made to this policy. This requirement includes antibodies, cell lines, and any newly created mutant animals. Animals can be made available through the authors' institution or via a publicly available repository. Other reagents, methods, etc., must be made available to the academic community. Failure to adhere to these guidelines will be considered a violation of the authorship agreement and could result in retraction of the published article.
Large datasets for gene expression microarrays, SNP arrays, and high-throughput sequencing studies must be deposited in a public repository. Microarray data must be deposited in a MIAME-compliant public database. High-throughput sequencing data must be deposited in a MINSEQE-compliant public database. The relevant accession numbers must appear in the main text of the manuscript. Deposition of other types of large datasets in a public repository is strongly encouraged. Other supporting datasets must be made available to any interested reader on the publication date from the authors directly. Researchers who encounter a persistent refusal by an author of a paper to comply with these guidelines should contact the Editors’ office by e-mail at firstname.lastname@example.org.
In general, JCI Insight adheres to guidelines established by the US Department of Health and Human Services’ Office of Research Integrity. For further information, refer to the Office’s website at http://ori.hhs.gov/.
Duplicate publication and scientific fraud are rare events that have a very serious impact on the integrity of the scientific community. If the Editors discover or are presented with evidence of such problems, the Editors will contact the appropriate official(s) at the institution(s) from which the manuscript originated. It is then left to the institution(s) in question to pursue the matter appropriately. Depending upon the circumstances, the journal may choose to publish errata, corrigenda, or expressions of concern, or to retract the manuscript in its entirety. If we detect any manipulation of images or figures prior to publication, we will automatically request all primary data for all figures for verification purposes.
When a member of the scientific community disagrees strongly with the methodology and/or conclusions of an article JCI Insight has published, but does not allege fraud, the Editors encourage the concerned individual to contact the authors of the article directly or to allow the natural corrective mechanisms of science to settle the issue with time.
JCI Insight and American Society for Clinical Investigation (ASCI) are dedicated to upholding the highest standards of integrity and ethical conduct in research, and in its evaluation and related communication. It is important that the editors, authors, and referees conduct themselves in accordance with stringent standards and transparent policies for addressing potential conflicts of interest. Herein, we delineate what constitutes a potential conflict of interest for JCI Insight as it relates to editors, authors, and referees. Those found in violation of these policies may be subject to sanctions as determined by the JCI Insight Editors.
The JCI Insight editors (Editor in Chief, Executive Editor, and Science Editors) are responsible for maintaining the highest possible standards in evaluating contributions to JCI Insight as well as for maintaining the integrity of the Journal. In the interest of establishing full transparency, editors are obliged to disclose any and all potential conflicts of interest to JCI Insight. We have determined two tiers of potential conflict and corresponding actions to be taken. The editors will report changes to their potential conflicts as they occur. An annual formal review of all disclosures will be performed in the evaluation of compliance.
If an editor declares a first-tier potential conflict relating to 1, 2, or 3, this information will be published on the JCI Insight website and the editor will be recused from editorial discussion and decisions related to the manuscript. An editor will be considered to be in conflict if a manuscript is funded solely by an organization with which the editor has a potential conflict, regardless of whether a research institution employs the authors.
The second tier of potential conflicts will necessitate only internal disclosure to the Editors and the JCI Insight staff. The editor in potential conflict will also be recused from editorial discussion and decisions related to the manuscript.
All authors are expected to disclose all financial relationships that could undermine the objectivity, integrity, or perceived value of a publication. The editors will keep the potential conflicts in mind while evaluating the manuscripts.
JCI Insight requires that all authors issue a statement disclosing all financial holdings, professional affiliations, advisory positions, board memberships, and patent holdings, as described below, even if they believe their conflict is not germane to the content of the submitted paper (these correspond to the first tier of potential conflicts defined for editors). Such potential conflicts will be published in a footnote if the manuscript is ultimately accepted. It is the responsibility of the corresponding author to gather the list of potential conflicts from each author and to communicate the list of all potential conflicts to the editors with the submission.
Any questions concerning these potential conflicts should be addressed to email@example.com.
Referees should exclude themselves in cases where there is a material potential conflict of interest, financial or otherwise. We ask that referees inform the editors of any potential conflicts that might be perceived as relevant as early as possible following invitation to participate in the review, and we will determine how to proceed. Disclosing a potential conflict does not invalidate the comments of a referee, it simply provides the editors with additional information relevant to the review.
We ask referees to use their judgment in responding to our request for full disclosure, basing their response to the editors on the same financial criteria applied to authors and editors, as described above.
Revised "Prior publication" to state that preprints are acceptable; removed all other items from this section, April 28, 2020.