ResearchIn-Press PreviewHepatologyInfectious disease
Open Access | 
10.1172/jci.insight.146883
Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver
Daniel Traum,1 Yue J. Wang,2 Kathleen B. Schwarz,3 Jonathan Schug,1 David K.H. Wong,4 Harry L.A. Janssen,4 Norah A. Terrault,5 Mandana Khalili,6 Abdus S. Wahed,7 Karen F. Murray,8 Philip Rosenthal,9 Simon C. Ling,10 Norberto Rodriguez-Baez,11 Richard K. Sterling,12 Daryl T.Y. Lau,13 Timothy M. Block,14 Michael D. Feldman,15 Emma E. Furth,15 William M. Lee,16 David E. Kleiner,17 Anna S. Lok,18 Klaus H. Kaestner,19 and Kyong-Mi Chang20
1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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Lee, W.
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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Lok, A.
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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1Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
2College of Medicine, Florida State University, Tallahassee, United States of America
3Department of Pediatrics, University of California, San Diego, San Diego, United States of America
4Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada
5Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, United States of America
6Department of Medicine, University of California, San Francisco, San Francisco, United States of America
7Department of Public Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, United States of America
8Pediatrics Institute, Cleveland Clinic, Cleveland, United States Minor Outlying Islands
9Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
10Department of Pediatrics, University of Toronto, Toronto, Canada
11Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, United States of America
12Department of Internal Medicine, Virginia Commonwealth University, Richmond, United States of America
13Department of Medicine, Beth Israel Deaconess Medical Center, Boston, United States of America
14Baruch S. Blumberg Institute, Doylestown, United States of America
15Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America
16Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
17Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America
18Department of Internal Medicine, Univerisity of Michigan, Ann Arbor, United States of America
19Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadeplhia, United States of America
20Department of Medical Research, The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States of America
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Published February 23, 2021 - More info
Copyright © 2021, Traum et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
