Strategies to overcome HBV-specific T cell exhaustion: checkpoint inhibitors and metabolic re-programming
P Fisicaro, C Boni, V Barili, D Laccabue… - Current opinion in …, 2018 - Elsevier
Highlights•Checkpoint blockade has limited efficacy in restoring HBV-specific T cell
functions.•Mitochondrial dysregulation is a key metabolic alteration in exhausted CD8
cells.•Combination with epigenetic drugs may increase the efficiency of PD-1
blockade.•Intervention on T cell metabolic defects can lead to final epigenetic
reprogramming.•A multi-target approach should be favored to maximize therapeutic
efficacy.HBV-specific T cells play a key role in antiviral protection and failure to control HBV …
functions.•Mitochondrial dysregulation is a key metabolic alteration in exhausted CD8
cells.•Combination with epigenetic drugs may increase the efficiency of PD-1
blockade.•Intervention on T cell metabolic defects can lead to final epigenetic
reprogramming.•A multi-target approach should be favored to maximize therapeutic
efficacy.HBV-specific T cells play a key role in antiviral protection and failure to control HBV …