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10.1172/jci.insight.166850
Upregulation of acid ceramidase contributes to tumor progression in Tuberous Sclerosis Complex
Aristotelis Astrinidis,1 Chenggang Li,1 Erik Y. Zhang,1 Xueheng Zhao,2 Shuyang Zhao,3 Minzhe Guo,3 Tasnim Olatoke,1 Ushodaya Mattam,1 Rong Huang,4 Alan Zhang,1 Lori Pitstick,1 Elizabeth J. Kopras,1 Nishant Gupta,1 Roman A. Jandarov,5 Eric P. Smith,1 Elizabeth Fugate,6 Diana Lindquist,6 Maciej M. Markiewski,7 Magdalena Karbowniczek,8 Kathryn A. Wikenheiser-Brokamp,9 Kenneth D. Setchell,10 Francis X. McCormack,1 Yan Xu,11 and Jane Yu1
1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, United States of America
2Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
3Divisions of Pulmonary Biology and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
4Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
5Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, United States of America
6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
7Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, United States of America
8Department of Immunotherapeutics and Biotechnology, Texas Tech Univsersity Health Sciences Center, Abilene, United States of America
9Division of Pathology and Laboratory Medicine, Division of Pulmonary Medici, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
10Division of Pathology and Laboratory Medicine, Children's Hospital Medical Center, Cincinnati, United States of America
11Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Instit, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
12Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinanti, United States of America
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Published March 16, 2023 - More info
Copyright © 2023, Astrinidis et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
