[HTML][HTML] Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-β and …
GA Finlay, B York, RH Karas, BL Fanburg… - Journal of Biological …, 2004 - ASBMB
The mechanisms that regulate the diverse responses to estrogen (E 2) are unknown. Loss of
function of the tuberous sclerosis 2 gene (TSC2), a tumor suppressor gene, has been
associated with a growth-promoting effect of E 2. We hypothesized that tuberin, the protein
product of TSC2, binds to estrogen receptors (ER) and regulates the growth effect of E 2. An
in vivo association between full-length tuberin and ERα was observed in HEK 293 cells and
ELT-3 smooth muscle cells. In contrast, poor association was observed between tuberin and …
function of the tuberous sclerosis 2 gene (TSC2), a tumor suppressor gene, has been
associated with a growth-promoting effect of E 2. We hypothesized that tuberin, the protein
product of TSC2, binds to estrogen receptors (ER) and regulates the growth effect of E 2. An
in vivo association between full-length tuberin and ERα was observed in HEK 293 cells and
ELT-3 smooth muscle cells. In contrast, poor association was observed between tuberin and …