Author's Take
In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Sitapriya Moorthi explains that the genomic landscape of lung cancer in older never-smoker women has unique patterns of mutations but is indistinguishable in its copy number alterations from smokers.
In this episode, Hsiang-Tsui Wang explains that targeting the interaction between aldehyde dehydrogenase 2 and acrolein, a byproduct of lipid peroxidation, may offer a therapeutic strategy for chronic kidney disease (CKD).
In this episode, Eduardo Vieira Neto explains that cardiolipin remodeling is deregulated in trifunctional protein deficiency leading to a reduction in mitochondrial oxygen consumption rate that contributes to the pathophysiology of this disease.
In this episode Rachael Gordon and Haylee Cosgrove describe how NOX2 deficiency exacerbates lupus but the cell types and mechanisms by which NOX2 exerts protective effects remain unknown. They show that NOX2 regulates lupus by its function in macrophages/monocytes and B cells, where it modulates TLR7 signaling.
In this episode, Lilei Zhang and Weiyi Xu present data from their iPSC-CM study together with clinical observations that support the use of B-vitamins to mitigate cardiac crises in TANGO2-deficient disorder (TDD) patients, providing alternative treatment strategies during life-threatening events.
