In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Peng Yao explains that FAM114A1 modulates cardiac fibrosis by regulating Ang II signaling and pharmacological inhibition of FAM114A1 is a therapeutic strategy for the treatment of heart disease.
In this episode, David Patrick describes a new mechanism responsible for systemic lupus erythematosus (SLE). IsoLGs accumulate in cells of patients with lupus and lupus prone mice. Scavenging of IsoLGs attenuates autoimmunity and hypertension in lupus prone mice. IsoLGs adduct to and inhibit the activity of PU.1. This suppresses the transcription of C1q subunits.
In this episode, Dr. Ramani Ramchandran explains that, in this study, the authors show that cilia on endothelial cells can disassemble under shear stress, and proteins from cilia can be tracked in fluids as a result of the disassembly process.
In this episode, Ghazaleh Tabatabai and colleagues discuss the landscape of tissue metabolites and corresponding transcripts in diffuse glioma assessed by NMR metabolomics and RNA sequening.
In this episode, Nardhy Gomez-Lopez explains how single-cell RNA-sequencing reveals the contributions of specific myometrial cell types to the biological processes implicated in term parturition.