ResearchIn-Press PreviewBone biologyTherapeutics
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10.1172/jci.insight.95042
Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva
Eleanor P. Williams,1 Jana Bagarova,2 Georgina Kerr,1 Dong-Dong Xia,2 Elsie S. Place,3 Devaveena Dey,2 Yue Shen,2 Geoffrey A. Bocobo,2 Agustin H. Mohedas,2 Xiuli Huang,4 Philip E. Sanderson,4 Arthur Lee,4 Wei Zheng,4 Aris N. Economides,5 James C. Smith,3 Paul B. Yu,2 and Alex N. Bullock1
1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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Williams, E.
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2Department of Medicine, Harvard Medical School, Boston, United States of America
3Developmental Biology Laboratory, Francis Crick Institute, London, United Kingdom
4National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, United States of America
5Skeletal Diseases TFA Group, Regeneron Pharmaceuticals, Inc, Tarrytown, United States of America
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Published March 11, 2021 - More info
Copyright © 2021, Williams et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
