Importance Oligomeric amyloid-β peptide binds to cellular prion protein on the neuronal cell
surface, activating intracellular fyn kinase to mediate synaptotoxicity and tauopathy.
AZD0530 is an investigational kinase inhibitor specific for the Src family, including fyn, that
has been repurposed for the treatment of Alzheimer disease. Objective To determine
whether AZD0530 treatment slows the decline in cerebral metabolic rate for glucose
(CMRgl) and is safe and well tolerated. Design, Setting, and Participants This multicenter …