ResearchIn-Press PreviewCell biologyGastroenterologyHepatology
Open Access | 
10.1172/jci.insight.195242
ETS1 suppresses Hepatic Stellate Cell activation and liver fibrosis
Wonseok Lee,1 Xiao Liu,1 Sara Brin Rosenthal,2 Charlene Miciano,3 Sadatsugu Sakane,1 Kanani Hokutan,1 Debanjan Dhar,1 Hyun Young Kim,1 David A. Brenner,4 and Tatiana Kisseleva5
1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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1Department of Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
2Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, United States of America
3Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, United States of America
4Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America
5Department of Surgery, University of California San Diego School of Medicine, La Jolla, United States of America
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Published November 4, 2025 - More info
Copyright © 2025, Lee et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
