ResearchIn-Press PreviewCell biologyOncology
Open Access | 
10.1172/jci.insight.193221
Therapeutic targeting of YOD1 disrupts the PAX-FOXO1-N-Myc feedback loop in rhabdomyosarcoma
Wenwen Ying,1 Jiayi Yu,2 Xiaomin Wang,1 Jiayi Liu,1 Boyu Deng,1 Xuejing Shao,1 Jinhu Wang,3 Ting Tao,3 Ji Cao,1 Qiaojun He,1 Bo Yang,1 Yifan Chen,1 and Meidan Ying1
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Ying, W. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Yu, J. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Wang, X. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Liu, J. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Deng, B. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Shao, X. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Wang, J. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by
Tao, T.
in:
PubMed
|
Google Scholar
|
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Cao, J. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by He, Q. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Yang, B. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Chen, Y. in: PubMed | Google Scholar
1Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory , College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2School of Pharmacy, Hangzhou Medical College, Hangzhou, China
3Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Find articles by Ying, M. in: PubMed | Google Scholar
Published December 16, 2025 - More info
Copyright © 2025, Ying et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
