ResearchIn-Press PreviewCell biologyNeuroscience
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10.1172/jci.insight.189634
Protein-protein interaction interfering peptide rescues dysregulated NMDA receptor signaling
Robert E. Featherstone,1 Hongbin Li,2 Ameet S. Sengar,2 Karin E. Borgmann-Winter,3 Olya Melnychenko,1 Lindsey M. Crown,1 Ray L. Gifford,1 Felix Amirfathi,1 Anamika Banerjee,4 AiVi Tran,1 Krishna Parekh,1 Margaret Heller,5 Wenyu Zhang,6 Robert J. Gallop,7 Adam D. Marc,6 Pragya Komal,2 Michael W. Salter,2 Steven J. Siegel,1 and Chang-Gyu Hahn3
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Featherstone, R. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Li, H. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
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1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Borgmann-Winter, K. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Melnychenko, O. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
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1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
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1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Amirfathi, F. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Banerjee, A. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
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1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
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1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Heller, M. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Zhang, W. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Gallop, R. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Marc, A. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Komal, P. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
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1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
Find articles by Siegel, S. in: PubMed | Google Scholar
1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, United States of America
2Neurosciences and Mental Health Program at SickKids Research Institute Toronto, Toronto, Canada
3Department of Psychiatry and Behavioral Sciences & Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
4Research and Development, Rocket Pharmaceuticals, Cranbury, United States of America
5Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, United States of America
6Department of Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States of America
7Department of Mathematics, West Chester University, West Chester, United States of America
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Published December 4, 2025 - More info
Copyright © 2025, Featherstone et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
