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Open Access | 10.1172/jci.insight.158030
1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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Sorgho, H.
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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Traore, O.
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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Kusi, K.
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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Williams, N.
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
2Department of Malaria, Antigen Discovery Inc., Irving, United States of America
3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique
5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of
6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso
7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana
8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana
9Department of Research, Antigen Discovery Inc., Irvine, United States of America
10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America
11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America
12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana
13Kintampo Health Research Centre, Kintampo, Ghana
14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain
15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya
16Kintampo Health Research Centre, Legon, Ghana
17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland
18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
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Published April 21, 2022 - More info
The RTS,S/AS01E vaccine targets the circumsporozoite protein (CSP) of the Plasmodium falciparum parasite. Using protein microarrays, levels of IgG to 1,000 P. falciparum antigens were measured in 2,138 infants (age 6-12 weeks) and children (age 5-17 months) from 6 African sites of the phase 3 trial, sampled before and at four longitudinal visits after vaccination. One month post-vaccination, IgG responses to 17% of all probed antigens showed differences between RTS,S/AS01E and comparator vaccination groups, whereas no prevaccination differences were found. A small subset of antigens presented IgG levels reaching 4- to 8 fold increases in the RTS,S/AS01E group, comparable in magnitude to anti-CSP IgG levels (~11-fold increase). They were strongly cross-correlated and correlated with anti CSP levels, waning similarly over time and re-increasing with the booster dose. Such an intriguing phenomenon may be due to cross-reactivity of anti-CSP antibodies with these antigens. RTS,S/AS01E vaccinees with strong off target IgG responses had an estimated lower clinical malaria incidence after adjusting for age group, site and post-vaccination anti-CSP levels. RTS,S/AS01E-induced IgG may bind strongly not only to CSP, but to unrelated malaria antigens, and this seems to either confer, or at least be a marker of, increased protection from clinical malaria.