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ResearchIn-Press PreviewImmunologyInfectious disease Open Access | 10.1172/jci.insight.158030

Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection

Dídac Macià,1 Joseph J. Campo,2 Gemma Moncunill,3 Chenjerai Jairoce,4 Augusto J. Nhabomba,4 Maximilian Mpina,5 Hermann Sorgho,6 David Dosoo,7 Ousmane Traore,6 Kwadwo A. Kusi,8 Nana Aba Williams,3 Amit Oberai,9 Arlo Randall,10 Hector Sanz,3 Clarissa Valim,11 Kwaku P. Asante,12 Seth Owusu-Agyei,13 Halidou Tinto,6 Selidji T. Agnandji,14 Simon Kariuki,15 Ben Gyan,13 Claudia Daubenberger,17 Benjamin Mordmüller,18 Paula Petrone,1 and Carlota Dobaño3

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Macià, D. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Campo, J. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Moncunill, G. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Jairoce, C. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Nhabomba, A. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Mpina, M. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Sorgho, H. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Dosoo, D. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Traore, O. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Kusi, K. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Williams, N. in: JCI | PubMed | Google Scholar |

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Oberai, A. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Randall, A. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Sanz, H. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Valim, C. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Asante, K. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Find articles by Petrone, P. in: JCI | PubMed | Google Scholar

1Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

2Department of Malaria, Antigen Discovery Inc., Irving, United States of America

3Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

5Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

6Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

7Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

8Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

9Department of Research, Antigen Discovery Inc., Irvine, United States of America

10Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

11Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

12Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

13Kintampo Health Research Centre, Kintampo, Ghana

14Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

15Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

16Kintampo Health Research Centre, Legon, Ghana

17Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

18Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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Published April 21, 2022 - More info

JCI Insight. https://doi.org/10.1172/jci.insight.158030.
Copyright © 2022, Macià et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published April 21, 2022 - Version history
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Abstract

The RTS,S/AS01E vaccine targets the circumsporozoite protein (CSP) of the Plasmodium falciparum parasite. Using protein microarrays, levels of IgG to 1,000 P. falciparum antigens were measured in 2,138 infants (age 6-12 weeks) and children (age 5-17 months) from 6 African sites of the phase 3 trial, sampled before and at four longitudinal visits after vaccination. One month post-vaccination, IgG responses to 17% of all probed antigens showed differences between RTS,S/AS01E and comparator vaccination groups, whereas no prevaccination differences were found. A small subset of antigens presented IgG levels reaching 4- to 8 fold increases in the RTS,S/AS01E group, comparable in magnitude to anti-CSP IgG levels (~11-fold increase). They were strongly cross-correlated and correlated with anti CSP levels, waning similarly over time and re-increasing with the booster dose. Such an intriguing phenomenon may be due to cross-reactivity of anti-CSP antibodies with these antigens. RTS,S/AS01E vaccinees with strong off target IgG responses had an estimated lower clinical malaria incidence after adjusting for age group, site and post-vaccination anti-CSP levels. RTS,S/AS01E-induced IgG may bind strongly not only to CSP, but to unrelated malaria antigens, and this seems to either confer, or at least be a marker of, increased protection from clinical malaria.

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