Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection

¹Department of Data Science, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

²Department of Malaria, Antigen Discovery Inc., Irving, United States of America

³Department of Malaria, ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

⁴Department of Malaria, Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique

⁵Department of Malaria, Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania, United Republic of

⁶Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de, Bobo-Dioulasso, Burkina Faso

⁷Laboratory, Kintampo Health Research Centre, Kintampo, Ghana

⁸Department of Electron Microscopy & Histopathology, NMIMR, College of Health Sciences, University of Ghana, Legon, Ghana

⁹Department of Research, Antigen Discovery Inc., Irvine, United States of America

¹⁰Department of Bioinformatics, Antigen Discovery Inc., Irvine, United States of America

¹¹Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, United States of America

¹²Department of Malaria, Kintampo Health Research Centre, Kintampo, Ghana

¹³Kintampo Health Research Centre, Kintampo, Ghana

¹⁴Department of Clinical Research, Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Spain

¹⁵Kenya Medical Research Institute/Centre for Global Health, Kisumu, Kenya

¹⁶Kintampo Health Research Centre, Legon, Ghana

¹⁷Department of Clinical Immunology, Swiss Tropical and Public Health Institute, Basel, Switzerland

¹⁸Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

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