Cross-reactive asparagine-rich determinants shared between several blood-stage antigens of Plasmodium falciparum and the circumsporozoite protein
F Ardeshir, RF Howard, S Viriyakosol, O Arad… - Molecular and …, 1990 - Elsevier
From a Plasmodium falciparum cDNA expression library derived from mRNA of the asexual
blood stages, we isolated and sequenced five different cDNA clones whose predicted
protein products were unusually rich in asparagine (Asn). Two of the clones, R5 and G5,
contain tandem imperfectly repeated sequences based on Asn-Asn-Thr (NNT) and Asn-Asn-
Met (NNM) respectively. The other three, E4, C5 and R13, as well as G5, contain stretches of
polyasparagine varying in length from 2 to 26 residues. Results of DNA blotting experiments …
blood stages, we isolated and sequenced five different cDNA clones whose predicted
protein products were unusually rich in asparagine (Asn). Two of the clones, R5 and G5,
contain tandem imperfectly repeated sequences based on Asn-Asn-Thr (NNT) and Asn-Asn-
Met (NNM) respectively. The other three, E4, C5 and R13, as well as G5, contain stretches of
polyasparagine varying in length from 2 to 26 residues. Results of DNA blotting experiments …
