[HTML][HTML] RTS, S Vaccination Is Associated With Serologic Evidence of Decreased Exposure to Plasmodium falciparum Liver-and Blood-Stage Parasites*[S]

JJ Campo, JJ Aponte, J Skinner, R Nakajima… - Molecular & Cellular …, 2015 - ASBMB
The leading malaria vaccine candidate, RTS, S, targets the sporozoite and liver stages of the
Plasmodium falciparum life cycle, yet it provides partial protection against disease
associated with the subsequent blood stage of infection. Antibodies against the vaccine
target, the circumsporozoite protein, have not shown sufficient correlation with risk of clinical
malaria to serve as a surrogate for protection. The mechanism by which a vaccine that
targets the asymptomatic sporozoite and liver stages protects against disease caused by …