ResearchIn-Press PreviewCell biologyOncology
Open Access | 
10.1172/jci.insight.202414
NOTCH1 acts as a tumor suppressor that induces early differentiation in head and neck cancer
Chenfei Huang,1 Shhyam Moorthy,2 Qiuli Li,2 Kazi M. Ahmed,1 Kalil Saab,1 Defeng Deng,1 Jiping Wang,2 Xiayu Rao,3 Jiexin Zhang,3 Yuanxin Xi,3 Jing Wang,3 Zhiyi Liu,2 Noriaki Tanaka,2 David A. Wheeler,4 Eve Shinbrot,4 Rami Saade,5 Curtis R. Pickering,2 Tong-Xin Xie,2 Adel K. El-Naggar,6 Abdullah A. Osman,2 Kunal Rai,7 Patrick A. Zweidler-McKay,8 John V. Heymach,9 Lauren A. Byers,9 Faye M. Johnson,9 Vlad C. Sandulache,1 Jeffrey N. Myers,2 Pedram Yadollahi,1 and Mitchell J. Frederick1
1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, United States of America
2Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
3Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America
5Department of Otolaryngology, Lebanese American University, Beirut, Lebanon
6Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
7Department of Genomic Medicine and MDACC Epigenomics Therapy Initiative, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
8Department of Pediatric Leukemia and Lymphoma, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
9Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, United States of America
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Published April 16, 2026 - More info
Copyright © 2026, Huang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
