ResearchIn-Press PreviewGeneticsNeuroscience
Open Access | 
10.1172/jci.insight.197941
KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS
Tetsuya Akiyama,1 Yi Zeng,1 Caiwei Guo,1 Olivia Gautier,1 Lauren Koepke,2 Heankel Lyons,1 Elana Molotsky,3 Juliane S. Bombosch,1 Odilia Sianto,1 Jay P. Ross,1 Phuong Hoang,1 Luke Zhao,1 Cole Spencer,1 Charlotte J. Sumner,3 Michelle Monje,2 John W. Day,4 and Aaron D. Gitler1
1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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1Department of Genetics, Stanford University School of Medicine, Stanford, United States of America
2Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology and Clinical Neurosciences, Stanford University, Stanford, United States of America
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Published March 26, 2026 - More info
Copyright © 2026, Akiyama et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
