ResearchIn-Press PreviewDermatologyOncologyTherapeutics
Open Access | 
10.1172/jci.insight.190287
CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity
Robert J. Fisher,1 Kihyun Park,1 Kwangwoon Lee,2 Katarina Pinjusic,3 Allison Vanasse,3 Christina S. Ennis,4 Parisa Farokh,5 Scott B. Ficarro,6 Jarrod A. Marto,6 Hanjie Jiang,2 Eunju Nam,2 Stephanie Stransky,7 Joseph Duke-Cohan,3 Melis A. Akinci,3 Anupa Geethadevi,8 Eric Raabe,8 Ana Fiszbein,9 Shadmehr Demehri,5 Simone Sidoli,7 Chad W. Hicks,10 Derin B. Keskin,3 Catherine J. Wu,3 Philip A. Cole,2 and Rhoda M. Alani1
1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
2Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women’s Hospital, Boston, United States of America
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
4Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
5Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, United States of America
7Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
8Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
9Department of Biology, Boston University, Boston, United States of America
10Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
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Published December 9, 2025 - More info
Copyright © 2025, Fisher et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
