Clinical Research and Public HealthIn-Press PreviewCOVID-19Clinical trialsInfectious disease
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10.1172/jci.insight.189150
A randomized, double-blind, placebo controlled trial of IL-7 in critically ill COVID-19 patients
Manu Shankar-Hari,1 Bruno Francois,2 Kenneth E. Remy,3 Cristina Gutierrez,4 Stephen Pastores,5 Thomas Daix,2 Robin Jeannet,2 Jane Blood,6 Andrew H. Walton,6 Reinaldo Salomao,7 Georg Auzinger,8 David Striker,9 Robert S. Martin,9 Nitin J. Anand,9 James Bosanquet,9 Teresa Blood,6 Scott Brakenridge,10 Lyle L. Moldawer,10 Vidula Vachharajani,11 Cassian Yee,4 Felipe Dal-Pizzol,12 Michel Morre,13 Frederique Berbille,13 Marcel van den Brink,14 and Richard Hotchkiss6
1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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1Department of Translational Critical Care Medicine, Centre for Inflammation, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom
2Medical-Surgical ICU & Inserm CIC 1435, Centre Hospitalier Universitaire, Limoges, France
3Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
4Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, United States of America
5Department of Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Anesthesiology, Washington University in St. Louis, School of Medicine, St. Louis, United States of America
7Department of Medicine, Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, Brazil
8Department of Intensive Care Medicine, King’s College Hospital, London, United Kingdom
9Department of Critical Care Medicine, Missouri Baptist Medical Center, St. Louis, United States of America
10Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, United States of America
11Department of Critical Care Medicine, Cleveland Clinic, Cleveland, United States of America
12Department of Medicine, Hospital Sao Jose, Criciuma, Brazil
13RevImmune, Paris, France
14City of Hope, Los Angeles, United States of America
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Published February 4, 2025 - More info
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