ResearchIn-Press PreviewInflammation
Open Access | 
10.1172/jci.insight.188028
Pro-inflammatory macrophages transporting gut-derived bacterial DNA drive autoimmune arthritis in spondyloarthropathy
Benjamin Cai,1 Rabina Giri,2 Amy J. Cameron,1 M. Arifur Rahman,1 Annabelle Small,3 Christopher Altmann,3 Yenkai Lim,1 Linda M. Rehaume,1 Mark Morrison,1 Mihir D. Wechalekar,5 Jakob Begun,2 Anne-Sophie Bergot,1 and Ranjeny Thomas1
1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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Bergot, A.
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1Frazer Institute, The University of Queensland, Brisbane, Australia
2Mater Research Institute, The University of Queensland, Brisbane, Australia
3College of Medicine & Public Health, Flinders University, Adelaide, Australia
4College of Medicine & Public Health, Flinders University, Australia
5College of Medicine & Public Health, Flinders Medical Centre, Adelaide, Australia
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Thomas, R.
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Published July 31, 2025 - More info
Copyright © 2025, Cai et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
