ResearchIn-Press PreviewNeuroscience Open Access | 10.1172/jci.insight.176329
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Deng, Y. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Zhang, Y. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Xu, D. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Zhang, X. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Chen, M. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
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1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Zhang, J. in: JCI | PubMed | Google Scholar |
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
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1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
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1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Cao, P. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Bi, L. in: JCI | PubMed | Google Scholar
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Pathology, Wuhan University, Wuhan, China
3Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
5Neuroscience, National Institute of Biological Sciences, Beijing, China
6Department of Radiology, Zhongnan Hospital of Wuhan Universety, Wuhan, China
Find articles by Xu, H. in: JCI | PubMed | Google Scholar
Published June 6, 2024 - More info
Sleep disturbance usually accompanies anxiety disorders and exacerbates their incidence rates. The precise circuit mechanisms remain poorly understood. Here, we found that glutamatergic neurons in the posteroventral medial amygdala (MePVGlu) are involved in arousal and anxiety-like behaviors. Excitation of MePVGlu neurons not only promoted wakefulness but also increased anxiety-like behaviors. Different projections of MePVGlu neurons played various roles in regulating anxiety-like behaviors and sleep-wakefulness. MePVGlu neurons promoted wakefulness through the MePVGlu-posteromedial cortical amygdaloid area (PMCo) pathway and the MePVGlu-bed nucleus of the stria terminals (BNST) pathway. In contrast, MePVGlu neurons increased anxiety-like behaviors through the MePVGlu-ventromedial hypothalamus (VMH) pathway. Chronic sleep disturbance increased anxiety levels and reduced reparative sleep, accompanied by the enhanced excitability of MePVGlu-PMCo and MePVGlu-VMH circuits but suppressed responses of glutamatergic neurons in the BNST. Inhibition of the MePVGlu neurons could rescue chronic sleep deprivation-induced phenotypes. Our findings provide important circuit mechanisms for chronic sleep disturbance-induced hyperarousal response and obsessive anxiety-like behavior, and are expected to provide a promising strategy for treating sleep-related psychiatric disorders and insomnia.