ResearchIn-Press PreviewOncology
Open Access | 
10.1172/jci.insight.173746
EZH2 deletion does not impact acinar regeneration but restricts progression to pancreatic cancer in mice
Emilie Jaune-Pons,1 Xiaoyi Wang,1 Fatemeh Mousavi,1 Zachary Klassen,1 Abdessamad Elkaoutari,2 Kurt Berger,3 Charis Johnson,4 Mickenzie B. Martin,1 Saloni Aggarwal,5 Sukhman Brar,5 Muhammad Khalid,5 Joanna F. Ryan,1 Parisa Shooshtari,3 Angela J. Mathison,2 Nelson Dusetti,7 Raul Urrutia,2 Gwen Lomberk,2 and Christopher L. Pin1
1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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1Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
2Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Canada
4Department of Paediatrics, University of Western Ontario, London, Canada
5Verspeeten Family Cancer Centre, London, Canada
6Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Med, Medical College of Wisconsin, Milwawkee, United States of America
7Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Marseille, France
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Published December 31, 2024 - More info
Copyright © 2024, Jaune-Pons et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
