Go to The Journal of Clinical Investigation
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Transfers
  • Advertising
  • Job board
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Immunology
    • Metabolism
    • Nephrology
    • Oncology
    • Pulmonology
    • All ...
  • Videos
  • Collections
    • Resource and Technical Advances
    • Clinical Medicine
    • Reviews
    • Editorials
    • Perspectives
    • Top read articles
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • In-Press Preview
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Transfers
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Supplemental material
  • Version history
  • Article usage
  • Citations to this article
Advertisement

ResearchIn-Press PreviewCell biologyMuscle biology Open Access | 10.1172/jci.insight.153584

NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression

Alexis Boulinguiez,1 Christian Duhem,1 Alicia Mayeuf-Louchart,1 Benoit Pourcet,1 Yasmine Sebti,1 Kateryna Kondratska,2 Valérie Montel,3 Stéphane Delhaye,1 Quentin Thorel,1 Justine Beauchamp,1 Aurore Hebras,1 Marion Gimenez,1 Marie Couvelaere,1 Mathilde Zecchin,1 Lise Ferri,1 Natalia Prevarskaya,4 Anne Forand,5 Christel Gentil,6 Jessica Ohana,7 France Piétri-Rouxel,6 Bruno Bastide,3 Bart Staels,1 Helene Duez,1 and Steve Lancel1

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Boulinguiez, A. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Duhem, C. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Mayeuf-Louchart, A. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Pourcet, B. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Sebti, Y. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Kondratska, K. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Montel, V. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Delhaye, S. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Thorel, Q. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Beauchamp, J. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Hebras, A. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Gimenez, M. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Couvelaere, M. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Zecchin, M. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Ferri, L. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Prevarskaya, N. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Forand, A. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Gentil, C. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Ohana, J. in: JCI | PubMed | Google Scholar

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Piétri-Rouxel, F. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Bastide, B. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Staels, B. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Duez, H. in: JCI | PubMed | Google Scholar |

1U1011-EGID, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

2U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm,, Villeneuve d'Ascq, France

3URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Lille, France

4U1003 - PHYCEL - Physiologie Cellulaire, University Lille, Inserm, Villeneuve d'Ascq, France

5INSERM U845, Université Paris Descartes, Paris, France

6INSERM UMRS_974, Institute of Myology, Paris, France

7MyoLine, Sorbonne Université-UMRS974-Inserm-Institut de Myologie, Paris, France

8URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale,, Loos, France

Find articles by Lancel, S. in: JCI | PubMed | Google Scholar |

Published August 2, 2022 - More info

JCI Insight. https://doi.org/10.1172/jci.insight.153584.
Copyright © 2022, Boulinguiez et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published August 2, 2022 - Version history
View PDF
Abstract

The sarcoplasmic reticulum (SR) plays an important role in calcium homeostasis. SR calcium mishandling is described in pathological conditions such as myopathies. Here, we investigated whether the nuclear receptor subfamily 1 group D member (NR1D1, also called REV-ERBα) regulates skeletal muscle SR calcium homeostasis. Our data demonstrate that NR1D1 deficiency in mice impairs SERCA-dependent SR calcium uptake. NR1D1 acts on calcium homeostasis by repressing the SERCA inhibitor myoregulin through direct binding to its promoter. Restoration of myoregulin counteracts the effects of NR1D1 overexpression on SR calcium content. Interestingly, myoblasts from Duchenne myopathy patients display lower NR1D1 expression, whereas pharmacological NR1D1 activation ameliorates SR calcium homeostasis, and improves muscle structure and function in dystrophic mdx/Utr+/- mice. Our findings demonstrate that NR1D1 regulates muscle SR calcium homeostasis, pointing to its therapeutic interest for mitigating myopathy.

Graphical Abstract
graphical abstract
Supplemental material

View

Version history
  • Version 1 (August 2, 2022): In-Press Preview

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Supplemental material
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN 2379-3708

Sign up for email alerts