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ResearchIn-Press PreviewCOVID-19 Open Access | 10.1172/jci.insight.143196

Clinical and laboratory evaluation of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma

Michele L. Donato,1 Steven Park,2 Melissa Baker,1 Robert Korngold,2 Alison Morawski,1 Xue Geng,3 Ming Tan,3 Andrew Ip,1 Stuart Goldberg,1 Scott D. Rowley,1 Kar F. Chow,1 Emily Brown,1 Joshua Zenreich,1 Phyllis McKiernan,1 Kathryn Buttner,1 Anna Ullrich,1 Laura Long,1 Rena Feinman,2 Andrea Ricourt,1 Marlo Kemp,1 Mariefel Vendivil,1 Hyung C. Suh,1 Bindu Balani,1 Cristina Cicogna,1 Rani Sebti,1 Abdulla Al-Khan,1 Steven J. Sperber,1 Samit Desai,4 Stacey L. Fanning,5 Danit Arad,4 Ronaldo C. Go,1 Elizabeth Tam,1 Keith Rose,1 Sean Sadikot,1 David S. Siegel,1 Martin Gutierrez,1 Tatyana Feldman,1 Andre Goy,1 Andrew Pecora,1 Noa Biran,1 Lori A. Leslie,1 Alfred Gillio,1 Sarah Timmapuri,1 Michele S. Boonstra,1 Sam Singer,1 Sukhdeep Kaur,1 Ernest Richards,1 and David S. Perlin2

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Donato, M. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Park, S. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Baker, M. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Korngold, R. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Morawski, A. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Geng, X. in: JCI | PubMed | Google Scholar |

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Goldberg, S. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Chow, K. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Brown, E. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Buttner, K. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Ullrich, A. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Long, L. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Al-Khan, A. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Sperber, S. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

Find articles by Tam, E. in: JCI | PubMed | Google Scholar

1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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1Department of Oncology, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

2Department of Oncology, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

3Department of Biostatistics, Georgetown University, Washington DC, United States of America

4Department of Infectious Disease, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America

5Department of Infectious Disease, Hackensack Meridian Health Center for Discovery and Innovation, Nutley, United States of America

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Published February 11, 2021 - More info

JCI Insight. https://doi.org/10.1172/jci.insight.143196.
Copyright © 2021, Donato et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published February 11, 2021 - Version history
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Abstract

We are reporting on a phase IIa study which aimed to determine the intubation rate, survival, viral clearance, and the development of endogenous antibodies in patients with COVID-19 pneumonia treated with convalescent plasma (CCP) containing high levels of neutralizing anti-SARS-CoV-2 antibodies. All 51 treated patients had COVID-19 pneumonia by radiographic and laboratory evaluation. Fresh or frozen CCP from donors with high titers of neutralizing antibodies was administered. The non-mechanically ventilated patients (n=36) had an intubation rate of 13.9% and a day-30 survival of 88.9%. The overall survival for a comparative group based on network data was 72.5% (1625/2241). Patients had rates of negative nasopharyngeal swab on day +10 and +30 of 43.8% and 73% respectively. Patients mechanically ventilated had a day-30 mortality of 46.7%; the mortality for a comparative group based on network data was 71% (369/520). All evaluable patients were found to have neutralizing antibodies on day +3 (n=47), and all but 1 had antibodies on day +30 and +60. The only adverse event was a mild rash. We are concluding that in this study of patients with COVID-19 pneumonia, CCP was safe and conferred transfer of antibodies while preserving endogenous immune response.

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