Citations to this article
Abstract
Here, we report on a phase IIa study to determine the intubation rate, survival, viral clearance, and development of endogenous Abs in patients with COVID-19 pneumonia treated with convalescent plasma (CCP) containing high levels of neutralizing anti–SARS-CoV-2 Abs. Radiographic and laboratory evaluation confirmed all 51 treated patients had COVID-19 pneumonia. Fresh or frozen CCP from donors with high titers of neutralizing Abs was administered. The nonmechanically ventilated patients (n = 36) had an intubation rate of 13.9% and a 30-day survival rate of 88.9%, and the overall survival rate for a comparative group based on network data was 72.5% (1625/2241). Patients had negative nasopharyngeal swab rates of 43.8% and 73.0% on days 10 and 30, respectively. Patients mechanically ventilated had a day-30 mortality rate of 46.7%; the mortality rate for a comparative group based on network data was 71.0% (369/520). All evaluable patients were found to have neutralizing Abs on day 3 (n = 47), and all but 1 patient had Abs on days 30 and 60. The only adverse event was a mild rash. In this study on patients with COVID-19 disease, we show therapeutic use of CCP was safe and conferred transfer of Abs, while preserving endogenous immune response.
Authors
Michele L. Donato, Steven Park, Melissa Baker, Robert Korngold, Alison Morawski, Xue Geng, Ming Tan, Andrew Ip, Stuart Goldberg, Scott Rowley, Kar Chow, Emily Brown, Joshua Zenreich, Phyllis McKiernan, Kathryn Buttner, Anna Ullrich, Laura Long, Rena Feinman, Andrea Ricourt, Marlo Kemp, Mariefel Vendivil, Hyung Suh, Bindu Balani, Cristina Cicogna, Rani Sebti, Abdulla Al-Khan, Steven Sperber, Samit Desai, Stacey Fanning, Danit Arad, Ronaldo Go, Elizabeth Tam, Keith Rose, Sean Sadikot, David Siegel, Martin Gutierrez, Tatyana Feldman, Andre Goy, Andrew Pecora, Noa Biran, Lori Leslie, Alfred Gillio, Sarah Timmapuri, Michele Boonstra, Sam Singer, Sukhdeep Kaur, Ernest Richards, David S. Perlin
Citation information
Citations to this article (30)
| Title and authors | Publication | Year |
|---|---|---|
|
Hyperimmune Plasma and Immunoglobulins against COVID-19: A Narrative Review
Franchini M, Focosi D |
Life Sciences | 2024 |
|
Convalescent plasma for people with COVID‐19: a living systematic review
Iannizzi C, Chai KL, Piechotta V, Valk SJ, Kimber C, Monsef I, Wood EM, Lamikanra AA, Roberts DJ, McQuilten Z, So-Osman C, Jindal A, Cryns N, Estcourt LJ, Kreuzberger N, Skoetz N |
The Cochrane Database of Systematic Reviews | 2023 |
|
Convalescent plasma for people with COVID‐19: a living systematic review
Iannizzi C, Chai KL, Piechotta V, Valk SJ, Kimber C, Monsef I, Wood EM, Lamikanra AA, Roberts DJ, McQuilten Z, So-Osman C, Jindal A, Cryns N, Estcourt LJ, Kreuzberger N, Skoetz N |
The Cochrane Database of Systematic Reviews | 2023 |
|
Molecular and Clinical Epidemiology of SARS-CoV-2 Infection among Vaccinated and Unvaccinated Individuals in a Large Healthcare Organization from New Jersey.
Mediavilla JR, Lozy T, Lee A, Kim J, Kan VW, Titova E, Amin A, Zody MC, Corvelo A, Oschwald DM, Baldwin A, Fennessey S, Zuckerman JM, Kirn T, Chen L, Zhao Y, Chow KF, Maniatis T, Perlin DS, Kreiswirth BN |
Viruses | 2023 |
|
Rates Among Hospitalized Patients With COVID-19 Treated With Convalescent Plasma: A Systematic Review and Meta-Analysis
Senefeld JW, Gorman EK, Johnson PW, Moir ME, Klassen SA, Carter RE, Paneth NS, Sullivan DJ, Morkeberg OH, Wright RS, Fairweather D, Bruno KA, Shoham S, Bloch EM, Focosi D, Henderson JP, Juskewitch JE, Pirofski LA, Grossman BJ, Tobian AA, Franchini M, Ganesh R, Hurt RT, Kay NE, Parikh SA, Baker SE, Buchholtz ZA, Buras MR, Clayburn AJ, Dennis JJ, Diaz Soto JC, Herasevich V, Klompas AM, Kunze KL, Larson KF, Mills JR, Regimbal RJ, Ripoll JG, Sexton MA, Shepherd JR, Stubbs JR, Theel ES, van Buskirk CM, van Helmond N, Vogt MN, Whelan ER, Wiggins CC, Winters JL, Casadevall A, Joyner MJ |
2023 | |
|
A Randomized Trial of Sitagliptin and Spironolactone With Combination Therapy in Hospitalized Adults With COVID-19
F Abbasi, R Adatorwovor, M Davarpanah, Y Mansoori, M Hajiani, F Azodi, S Sefidbakht, S Davoudi, F Rezaei, S Mohammadmoradi, K Asadipooya |
Journal of the Endocrine Society | 2022 |
|
Early administration of COVID ‐19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy
A Belov, Y Huang, C Villa, B Whitaker, R Forshee, S Anderson, A Eder, N Verdun, M Joyner, S Wright, R Carter, D Hung, M Homer, C Hoffman, M Lauer, P Marks |
American Journal of Hematology | 2022 |
|
Improved Survival of Lymphoma Patients with COVID-19 in the Modern Treatment and Vaccination Era
Della Pia A, Zhao C, Jandir P, Gupta A, Batistick M, Kim GY, Xia Y, Ahn J, Magarelli G, Lukasik B, Leslie LA, Goy AH, Ip A, Feldman TA |
Cancers | 2022 |
|
Characterization of pathogen‐inactivated COVID‐19 convalescent plasma and responses in transfused patients
Weisser M, Khanna N, Hedstueck A, Sutter ST, Roesch S, Stehle G, Sava M, Deigendesch N, Battegay M, Infanti L, Holbro A, Bassetti S, Pargger H, Hirsch HH, Leuzinger K, Kaiser L, Vu D, Baur K, Massaro N, Busch MP, Simmons G, Stone M, Felgner PL, de Assis RR, Khan S, Tsai C, Robinson PV, Seftel D, Irsch J, Bagri A, Buser AS, Corash L |
Transfusion | 2022 |
|
Evaluation of a COVID-19 convalescent plasma program at a U.S. academic medical center
Root HB, Gilleskie M, Lu CH, Gilmore A, Evans M, Nelson BG, Johnson W, Gurney B, Kuruc J, Markmann AJ, Barzin AH, Wohl DA, Fischer WA, Park YA, Weiss S, Napravnik S, Baric R, de Silva AM, Lachiewicz AM, van Duin D, Margolis DM, Herce ME, Bartelt LA |
PloS one | 2022 |
|
Treatment of Severe COVID-19 with Convalescent Plasma in Bronx, NYC
Hyun ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H. Bortz III, Ariel S. Wirchnianski, Monika Paroder, Karen Fehn, Leana Serrano-Rahman, Rachelle Babb, Uzma N. Sarwar, Denise Haslwanter, Ethan Laudermilch, Catalina Florez, M. Eugenia Dieterle, Rohit K Jangra, J. Maximilian Fels, Karen Tong, Margarette C. Mariano, Olivia Vergnolle, George I. Georgiev, Natalia G. Herrera, Ryan J. Malonis, Jose A. Quiroz, Nicholas C. Morano, Gregory J. Krause, Joseph M. Sweeney, Kelsie Cowman, Stephanie A Allen, Jayabhargav Annam, Ariella Applebaum, Daniel Barboto, Ahmed Khokhar, Brianna J. Lally, Audrey Lee, Max Lee, Avinash Malaviya, Reise Sample, Xiuyi A Yang, Yang Li, Rafael E Ruiz, Raja Thota, Jason Barnhill, Doctor Y. Goldstein, Joan Uehlinger, Scott J. Garforth, Steven C. Almo, Jonathan R. Lai, Morayma Reyes Gil, Amy S. Fox, Kartik Chandran, Tao Wang, Johanna P Daily, Liise-anne Pirofski |
JCI Insight | 2021 |
|
Convalescent Plasma for Infectious Diseases: Historical Framework and Use in COVID-19
JG Ripoll, N van Helmond, JW Senefeld, CC Wiggins, SA Klassen, SE Baker, KF Larson, BM Murphy, KJ Andersen, SK Ford, A Casadevall, MJ Joyner |
Clinical Microbiology Newsletter | 2021 |
|
Effect of time and titer in convalescent plasma therapy for COVID-19
P de Candia, F Prattichizzo, S Garavelli, RL Grotta, AD Rosa, A Pontarelli, R Parrella, A Ceriello, G Matarese |
iScience | 2021 |
|
Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence
SA Klassen, JW Senefeld, KA Senese, PW Johnson, CC Wiggins, SE Baker, N van Helmond, KA Bruno, L Pirofski, S Shoham, BJ Grossman, JP Henderson, RS Wright, DL Fairweather, NS Paneth, RE Carter, A Casadevall, MJ Joyner |
Frontiers in Medicine | 2021 |
|
The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis
SA Klassen, JW Senefeld, PW Johnson, RE Carter, CC Wiggins, S Shoham, BJ Grossman, JP Henderson, J Musser, E Salazar, WR Hartman, NM Bouvier, ST Liu, L Pirofski, SE Baker, N van Helmond, RS Wright, DL Fairweather, KA Bruno, Z Wang, NS Paneth, A Casadevall, MJ Joyner |
Mayo Clinic Proceedings | 2021 |
|
Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma
SL Fanning, R Korngold, Z Yang, K Goldgirsh, S Park, J Zenreich, M Baker, P McKiernan, M Tan, B Zhang, ML Donato, DS Perlin, SR Shih |
PLoS pathogens | 2021 |
|
Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review
V Piechotta, C Iannizzi, KL Chai, SJ Valk, C Kimber, E Dorando, I Monsef, EM Wood, AA Lamikanra, DJ Roberts, Z McQuilten, C So-Osman, LJ Estcourt, N Skoetz |
Cochrane Database of Systematic Reviews | 2021 |
|
Mortality Benefit of Convalescent Plasma in COVID-19: A Systematic Review and Meta-Analysis
V Bansal, KS Mahapure, I Mehra, A Bhurwal, A Tekin, R Singh, I Gupta, SS Rathore, H Khan, S Deshpande, S Gulati, P Armaly, M Sheraton, R Kashyap |
Frontiers in Medicine | 2021 |
|
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
MJ Joyner, RE Carter, JW Senefeld, SA Klassen, JR Mills, PW Johnson, ES Theel, CC Wiggins, KA Bruno, AM Klompas, ER Lesser, KL Kunze, MA Sexton, JC Soto, SE Baker, JR Shepherd, N van Helmond, NC Verdun, P Marks, CM van Buskirk, JL Winters, JR Stubbs, RF Rea, DO Hodge, V Herasevich, ER Whelan, AJ Clayburn, KF Larson, JG Ripoll, KJ Andersen, MR Buras, MN Vogt, JJ Dennis, RJ Regimbal, PR Bauer, JE Blair, NS Paneth, DL Fairweather, RS Wright, A Casadevall |
New England Journal of Medicine | 2021 |
|
Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India
K Nayak, K Gottimukkala, S Kumar, ES Reddy, VV Edara, R Kauffman, K Floyd, G Mantus, D Savargaonkar, PK Goel, S Arora, M Rahi, CW Davis, S Linderman, J Wrammert, MS Suthar, R Ahmed, A Sharma, K Murali-Krishna, A Chandele |
Virology | 2021 |
|
Convalescent Plasma Transfusion for the Treatment of COVID-19 in Adults: A Global Perspective
S Kanj, B Al-Omari |
Viruses | 2021 |
|
The role and uses of antibodies in COVID-19 infections: a living review
DO Scourfield, SG Reed, M Quastel, J Alderson, VM Bart, AT Crespo, R Jones, E Pring, FC Richter, DJ Ahern, H Almuttaqi, DS Alonzi, A Alrubayyi, G Alsaleh, VM Bart, V Batchelor, R Bayliss, DL Berthold, JS Bezbradica, T Bharuchq, H Borrmann, M Borsa, R Borst, J Brun, SE Burnell, L Capitani, A Cavounidis, L Chapman, A Chauveau, L Cifuentes, AS Codd, EB Compeer, C Coveney, A Cross, S Danielli, LC Davies, CA Dendrou, S Dimonte, RR Durairaj, LB Dustin, A Dyer, C Fielding, F Fischer, A Gallimore, S Galloway, A Gammage, E Gea-Mallorquí, A Godkin, SJ Hanna, C Heuberger, S Hulin-Curtis, F Issa, E Jones, R Jones, K Ladell, SN Lauder, K Liddiard, P Ligoxygakis, F Lu, B MacLachlan, S Maleki-Toyserkani, EH Mann, AM Marzeda, RJ Matthews, JM Mazet, A Milicic, E Mitchell, O Moon, VD Nguyen, M O'Hanlon, CE Pavillet, D Peppa, A Pires, E Pring, M Quastel, S Reed, J Rehwinkel, N Richmond, FC Richter, AJ Robinson, PR Rodrigues, P Sabberwal, A Sami, RS Peres, Q Sattentau, B Schonfeldova, DO Scourfield, TA Selvakumar, FR Shepherd, C Shorten, AK Simon, AL Smith, AT Crespo, M Tellier, E Thornton, LF Uhl, E van Grinsven, AK Wann, R Williams, JD Wilson, D Zhou, Z Zhu, SE Burnell |
2021 | |
|
Antifungal Drug Susceptibility and Genetic Characterization of Fungi Recovered from COVID-19 Patients
M Kordalewska, KD Guerrero, R Garcia-Rubio, C Jiménez-Ortigosa, JR Mediavilla, MH Cunningham, F Hollis, T Hong, KF Chow, BN Kreiswirth, DS Perlin |
Journal of Fungi | 2021 |
|
A Phase II Study on the Use of Convalescent Plasma for the Treatment of Severe COVID-19- A Propensity Score-Matched Control Analysis
V Pappa, A Bouchla, E Terpos, TP Thomopoulos, M Rosati, D Stellas, A Antoniadou, A Mentis, SG Papageorgiou, M Politou, A Kotanidou, I Kalomenidis, G Poulakou, E Jahaj, E Korompoki, S Grigoropoulou, X Hu, J Bear, S Karaliota, R Burns, M Pagoni, I Trontzas, E Grouzi, S Labropoulou, K Stamoulis, A Bamias, S Tsiodras, BK Felber, GN Pavlakis, MA Dimopoulos |
Microorganisms | 2021 |
|
Current views on the potentials of convalescent plasma therapy (CPT) as Coronavirus disease 2019 (COVID‐19) treatment: A systematic review and meta‐analysis based on recent studies and previous respiratory pandemics
JK Aviani, D Halim, AY Soeroto, TH Achmad, T Djuwantono |
Reviews in Medical Virology | 2021 |
|
Effect of Immunosuppressive Diseases and Rituximab Infusions on Allowing COVID-19 Infection to Relapse
Prasad RM, Srivastava S, Wang E, Liu JZ, Gami R, Abdelgadir A, Sharma A, Rayamajhi S, Tikaria R |
The Permanente journal | 2021 |
|
Convalescent Plasma Use in the United States was inversely correlated with COVID-19 Mortality: Did Plasma Hesitancy cost lives?
Casadevall A, Dragotakes Q, Johnson PW, Senefeld JW, Klassen SA, Wright RS, Joyner MJ, Paneth N, Carter RE |
2021 | |
|
Safety and efficacy of convalescent plasma therapy in severely and critically ill patients with COVID-19: a systematic review with meta-analysis
L Wenjing, F Yuanzheng, JY Li, LV Tang, H Yu |
Aging | 2020 |
|
Convalescent plasma may be a possible treatment for COVID-19: A systematic review
Wang Y, Huo P, Dai R, Lv X, Yuan S, Zhang Y, Guo Y, Li R, Yu Q, Zhu K |
International Immunopharmacology | 2020 |
|
Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC.
Yoon HA, Bartash R, Gendlina I, Rivera J, Nakouzi A, Bortz RH 3rd, Wirchnianski AS, Paroder M, Fehn K, Serrano-Rahman L, Babb R, Sarwar UN, Haslwanter D, Laudermilch E, Florez C, Dieterle ME, Jangra RK, Fels JM, Tong K, Mariano MC, Vergnolle O, Georgiev GI, Herrera NG, Malonis RJ, Quiroz JA, Morano NC, Krause GJ, Sweeney JM, Cowman K, Allen S, Annam J, Applebaum A, Barboto D, Khokhar A, Lally BJ, Lee A, Lee M, Malaviya A, Sample R, Yang XA, Li Y, Ruiz R, Thota R, Barnhill J, Goldstein DY, Uehlinger J, Garforth SJ, Almo SC, Lai JR, Gil MR, Fox AS, Chandran K, Wang T, Daily JP, Pirofski LA |
medRxiv : the preprint server for health sciences | 2020 |
