ResearchIn-Press PreviewAIDS/HIVImmunology
Open Access | 10.1172/jci.insight.136648
1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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Rutishauser, R.
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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Hiatt, J.
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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Roth, T.
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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Hecht, F.
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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1Department of Medicine, University of California, San Francisco, San Franciscoo, United States of America
2Department of Medicine, University of California, San Francisco, San Francisco, United States of America
3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States of America
4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, United States of America
5Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
7Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States of America
8Department of Medicine, University of California, San Franciso, San Francisco, United States of America
9Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Department of Pathology, Case Western Reserve University, Cleveland, United States of America
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Published December 22, 2020 - More info
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate secondary effector cells) is a key feature of exhaustion; little is known, however, about how these properties are regulated in human virus-specific CD8+ T cells. We found that virus-specific CD8+ T cells from humans and non-human primates naturally controlling HIV/SIV infection express more of the transcription factor, TCF-1, than non-controllers. HIV-specific CD8+ T cell TCF-1 expression correlated with memory marker expression and expansion capacity and declined with antigenic stimulation. CRISPR-Cas9 editing of TCF-1 in human primary T cells demonstrated a direct role in regulating expansion capacity. Collectively, these data suggest that TCF-1 contributes to the regulation of the stem-like memory property of secondary expansion capacity of HIV-specific CD8+ T cells, and they provide a rationale for exploring the enhancement of this pathway in T cell-based therapeutic strategies for HIV.