Differential Impact of Magnitude, Polyfunctional Capacity, and Specificity of HIV-Specific CD8+ T Cell Responses on HIV Set Point
Journal of virology, 2014•Am Soc Microbiol
Defining the characteristics of HIV-specific CD8+ T cell responses that lead to viral control is
crucial for vaccine development. We evaluated the differential impact of magnitude,
polyfunctional capacity, and specificity of the CD8+ response at approximately 6 months
postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High
frequencies of Gag and Nef responses endowed with four functions were the best predictors
of a low viral set point.
crucial for vaccine development. We evaluated the differential impact of magnitude,
polyfunctional capacity, and specificity of the CD8+ response at approximately 6 months
postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High
frequencies of Gag and Nef responses endowed with four functions were the best predictors
of a low viral set point.
Abstract
Defining the characteristics of HIV-specific CD8+ T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8+ response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point.
American Society for Microbiology