Base editing in human primary muscle stem cells and mutation repair

In this episode, Helena Escobar and Simone Spuler explain that patient primary muscle stems cells gene repaired with greater than 90% efficiency by base editing maintain their regenerative properties for autologous cell replacement therapies of muscular dystrophy.

Peptide recognition by T and B cells in rheumatoid arthritis

In this episode, Jane Buckner discusses how citrullinated tenascin-C is an autoantigen that is targeted by autoreactive CD4+ T cells and autoantibodies in patients with rheumatoid arthritis.

Humanized mouse models of MC4R-linked obesity

In this episode, Michel Bouvier explains the present study aimed at testing pharmacological chaperones in humanized MC4R mouses model as potential therapeutic treatment of melanocortin type 4 receptor linked obesity.

Aging and T cells during recovery from influenza pneumonia

The age-related pro-repair function of Treg cells following influenza infection is determined by cell-autonomous mechanisms.

Protection against iatrogenically induced hearing loss

In this episode, Marisa Zallocchi explains how treatment with quinoxaline derivatives protects from aminoglycoside- and cisplatin-hearing loss by NF-kB inhibition.