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Videos

Gut inflammation in mice is alleviated by glucose-dependent insulinotropic polypeptide receptor

In this episode, Rola Hammoud explains that the paper demonstrates that activation versus loss of GIP action impacts the extent of experimental gut inflammation in mice.


The Women’s Health Initiative and lung cancer in never-smokers

In this episode, Sitapriya Moorthi explains that the genomic landscape of lung cancer in older never-smoker women has unique patterns of mutations but is indistinguishable in its copy number alterations from smokers.


Preserving kidney function with aldehyde dehydrogenase 2

In this episode, Hsiang-Tsui Wang explains that targeting the interaction between aldehyde dehydrogenase 2 and acrolein, a byproduct of lipid peroxidation, may offer a therapeutic strategy for chronic kidney disease (CKD).


Remodeling abnormalities in mitochondrial trifunctional protein deficiency

In this episode, Eduardo Vieira Neto explains that cardiolipin remodeling is deregulated in trifunctional protein deficiency leading to a reduction in mitochondrial oxygen consumption rate that contributes to the pathophysiology of this disease.


Murine lupus protection and regulation of TLR7

In this episode Rachael Gordon and Haylee Cosgrove describe how NOX2 deficiency exacerbates lupus but the cell types and mechanisms by which NOX2 exerts protective effects remain unknown. They show that NOX2 regulates lupus by its function in macrophages/monocytes and B cells, where it modulates TLR7 signaling.

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