Corrigendum Free access | 10.1172/jci.insight.94086
Find articles by Ding, Y. in: JCI | PubMed | Google Scholar
Find articles by Long, P. in: JCI | PubMed | Google Scholar
Find articles by Bos, J. in: JCI | PubMed | Google Scholar
Find articles by Shih, Y. in: JCI | PubMed | Google Scholar
Find articles by Ma, X. in: JCI | PubMed | Google Scholar
Find articles by Sundsbak, R. in: JCI | PubMed | Google Scholar
Find articles by Chen, J. in: JCI | PubMed | Google Scholar
Find articles by Jiang, Y. in: JCI | PubMed | Google Scholar
Find articles by Zhao, L. in: JCI | PubMed | Google Scholar
Find articles by Hu, X. in: JCI | PubMed | Google Scholar
Find articles by Wang, J. in: JCI | PubMed | Google Scholar
Find articles by Shi, Y. in: JCI | PubMed | Google Scholar
Find articles by Ackerman, M. in: JCI | PubMed | Google Scholar
Find articles by Lin, X. in: JCI | PubMed | Google Scholar
Find articles by Ekker, S. in: JCI | PubMed | Google Scholar
Find articles by Redfield, M. in: JCI | PubMed | Google Scholar
Find articles by Olson, T. in: JCI | PubMed | Google Scholar
Find articles by Xu, X. in: JCI | PubMed | Google Scholar
Published April 20, 2017 - More info
Mutagenesis screening is a powerful forward genetic approach that has been successfully applied in lower-model organisms to discover genetic factors for biological processes. This phenotype-based approach has yet to be established in vertebrates for probing major human diseases, largely because of the complexity of colony management. Herein, we report a rapid strategy for identifying genetic modifiers of cardiomyopathy (CM). Based on the application of doxorubicin stress to zebrafish insertional cardiac (ZIC) mutants, we identified 4 candidate CM-modifying genes, of which 3 have been linked previously to CM. The long isoform of DnaJ (Hsp40) homolog, subfamily B, member 6b (
Yonghe Ding, Pamela A. Long, J. Martijn Bos, Yu-Huan Shih, Xiao Ma, Rhianna S. Sundsbak, Jianhua Chen, Yiwen Jiang, Liqun Zhao, Xinyang Hu, Jianan Wang, Yongyong Shi, Michael J. Ackerman, Xueying Lin, Stephen C. Ekker, Margaret M. Redfield, Timothy M. Olson, Xiaolei Xu
Original citation: JCI Insight. 2016;1(14):e88797. https://doi.org/10.1172/jci.insight.88797
Citation for this corrigendum: JCI Insight. 2017;2(8):e94086. https://doi.org/10.1172/jci.insight.94086
In Table 2, the nucleotide change resulting in the p.F93F variant of DNAJB6 was incorrectly noted. The correct table is below.
The authors regret the error.
See the related article at A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.