Citations to this article
Abstract
The strong association of Zika virus infection with congenital defects has led to questions of how a flavivirus is capable of crossing the placental barrier to reach the fetal brain. Here, we demonstrate permissive Zika virus infection of primary human placental macrophages, commonly referred to as Hofbauer cells, and placental villous fibroblasts. We also demonstrate Zika virus infection of Hofbauer cells within the context of the tissue ex vivo using term placental villous explants. In addition to amplifying infectious virus within a usually inaccessible area, the putative migratory activities of Hofbauer cells may aid in dissemination of Zika virus to the fetal brain. Understanding the susceptibility of placenta-specific cell types will aid future work around and understanding of Zika virus–associated pregnancy complications.
Authors
Kellie Ann Jurado, Michael K. Simoni, Zhonghua Tang, Ryuta Uraki, Jesse Hwang, Sarah Householder, Mingjie Wu, Brett D. Lindenbach, Vikki M. Abrahams, Seth Guller, Erol Fikrig
Total citations by year
Citation information
Citations to this article in year 2017 (19)
| Title and authors | Publication | Year |
|---|---|---|
|
The role of viral infections on pregnancy outcome, fetal development and maternal health
Karen Racicot, Gil Mor |
Journal of Clinical Investigation | 2017 |
|
Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice
B Cao, LA Parnell, MS Diamond, IU Mysorekar |
Journal of Experimental Medicine | 2017 |
|
Immune Cell Dynamics in Rhesus Macaques Infected with a Brazilian Strain of Zika Virus
EL Silveira, KA Rogers, S Gumber, P Amancha, P Xiao, SM Woollard, SN Byrareddy, MM Teixeira, F Villinger |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
|
Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy
SS Foo, W Chen, Y Chan, JW Bowman, LC Chang, Y Choi, JS Yoo, J Ge, G Cheng, A Bonnin, K Nielsen-Saines, P Brasil, JU Jung |
Nature Microbiology | 2017 |
|
Zika virus causes testicular atrophy
R Uraki, J Hwang, KA Jurado, S Householder, LJ Yockey, AK Hastings, RJ Homer, A Iwasaki, E Fikrig |
Science Advances | 2017 |
|
Vulnerability of primitive human placental trophoblast to Zika virus
MA Sheridan, D Yunusov, V Balaraman, AP Alexenko, S Yabe, S Verjovski-Almeida, DJ Schust, AW Franz, Y Sadovsky, T Ezashi, RM Roberts |
Proceedings of the National Academy of Sciences | 2017 |
|
Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus
K Rausch, BA Hackett, NL Weinbren, SM Reeder, Y Sadovsky, CA Hunter, DC Schultz, CB Coyne, S Cherry |
Cell Reports | 2017 |
|
Viral infection, proliferation, and hyperplasia of Hofbauer cells and absence of inflammation characterize the placental pathology of fetuses with congenital Zika virus infection
DA Schwartz |
Archives of Gynecology and Obstetrics | 2017 |
|
Potential mechanisms of Zika-linked microcephaly: Zika-linked microcephaly
E Merfeld, L Ben-Avi, M Kennon, KL Cerveny |
Wiley Interdisciplinary Reviews Developmental Biology | 2017 |
|
Maternal-Fetal Transmission of Zika Virus: Routes and Signals for Infection
B Cao, MS Diamond, IU Mysorekar |
Journal of Interferon & Cytokine Research | 2017 |
|
TAM Receptors Are Not Required for Zika Virus Infection in Mice
AK Hastings, LJ Yockey, BW Jagger, J Hwang, R Uraki, HF Gaitsch, LA Parnell, B Cao, IU Mysorekar, CV Rothlin, E Fikrig, MS Diamond, A Iwasaki |
Cell Reports | 2017 |
|
Case Report: Microcephaly in Twins due to the Zika Virus
SJ Oliveira, RQ Gurgel, DR Lima, CA Santos, PR Martins-Filho, VS Santos |
The American journal of tropical medicine and hygiene | 2017 |
|
Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero
BW Jagger, JJ Miner, B Cao, N Arora, AM Smith, A Kovacs, IU Mysorekar, CB Coyne, MS Diamond |
Cell Host & Microbe | 2017 |
|
Is Zika Virus an Emerging TORCH Agent? An Invited Commentary
Z Mehrjardi |
Virology : research and treatment | 2017 |
|
Severe Neurologic Disorders in 2 Fetuses with Zika Virus Infection, Colombia
J Acosta-Reyes, E Navarro, MJ Herrera, E Goenaga, ML Ospina, E Parra, M Mercado, P Chaparro, M Beltran, ML Gunturiz, L Pardo, C Valencia, S Huertas, J Rodríguez, G Ruiz, D Valencia, LB Haddad, SC Tinker, CA Moore, H Baquero |
Emerging infectious diseases | 2017 |
|
Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling
A Bayer, NJ Lennemann, Y Ouyang, E Sadovsky, MA Sheridan, RM Roberts, CB Coyne, Y Sadovsky |
Placenta | 2017 |
|
Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network
MT Aliota, L Bassit, SS Bradrick, B Cox, MA Garcia-Blanco, C Gavegnano, TC Friedrich, TG Golos, DE Griffin, AD Haddow, EG Kallas, U Kitron, M Lecuit, DM Magnani, C Marrs, N Mercer, E McSweegan, LF Ng, DH O'Connor, JE Osorio, GS Ribeiro, M Ricciardi, SL Rossi, G Saade, RF Schinazi, GO Schott-Lerner, C Shan, PY Shi, DI Watkins, N Vasilakis, SC Weaver |
Antiviral Research | 2017 |
|
Maternal-fetal transmission of the zika virus: An intriguing interplay
C Zanluca, L de Noronha, CN dos Santos |
Tissue Barriers | 2017 |
|
Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
MR Salick, MF Wells, K Eggan, A Kaykas |
Journal of visualized experiments : JoVE | 2017 |
