Citations to this article
Kellie Ann Jurado, … , Seth Guller, Erol Fikrig
Published August 18, 2016
Citation Information: JCI Insight. 2016;1(13):e88461. https://doi.org/10.1172/jci.insight.88461.
Citation Information: JCI Insight. 2016;1(13):e88461. https://doi.org/10.1172/jci.insight.88461.
Abstract
The strong association of Zika virus infection with congenital defects has led to questions of how a flavivirus is capable of crossing the placental barrier to reach the fetal brain. Here, we demonstrate permissive Zika virus infection of primary human placental macrophages, commonly referred to as Hofbauer cells, and placental villous fibroblasts. We also demonstrate Zika virus infection of Hofbauer cells within the context of the tissue ex vivo using term placental villous explants. In addition to amplifying infectious virus within a usually inaccessible area, the putative migratory activities of Hofbauer cells may aid in dissemination of Zika virus to the fetal brain. Understanding the susceptibility of placenta-specific cell types will aid future work around and understanding of Zika virus–associated pregnancy complications.
Authors
Kellie Ann Jurado, Michael K. Simoni, Zhonghua Tang, Ryuta Uraki, Jesse Hwang, Sarah Householder, Mingjie Wu, Brett D. Lindenbach, Vikki M. Abrahams, Seth Guller, Erol Fikrig
Total citations by year
Citation information
Citations to this article (107)
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Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero
BW Jagger, JJ Miner, B Cao, N Arora, AM Smith, A Kovacs, IU Mysorekar, CB Coyne, MS Diamond |
Cell Host & Microbe | 2017 |
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Is Zika Virus an Emerging TORCH Agent? An Invited Commentary
Z Mehrjardi |
Virology : research and treatment | 2017 |
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Severe Neurologic Disorders in 2 Fetuses with Zika Virus Infection, Colombia
J Acosta-Reyes, E Navarro, MJ Herrera, E Goenaga, ML Ospina, E Parra, M Mercado, P Chaparro, M Beltran, ML Gunturiz, L Pardo, C Valencia, S Huertas, J Rodríguez, G Ruiz, D Valencia, LB Haddad, SC Tinker, CA Moore, H Baquero |
Emerging infectious diseases | 2017 |
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Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling
A Bayer, NJ Lennemann, Y Ouyang, E Sadovsky, MA Sheridan, RM Roberts, CB Coyne, Y Sadovsky |
Placenta | 2017 |
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Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network
MT Aliota, L Bassit, SS Bradrick, B Cox, MA Garcia-Blanco, C Gavegnano, TC Friedrich, TG Golos, DE Griffin, AD Haddow, EG Kallas, U Kitron, M Lecuit, DM Magnani, C Marrs, N Mercer, E McSweegan, LF Ng, DH O'Connor, JE Osorio, GS Ribeiro, M Ricciardi, SL Rossi, G Saade, RF Schinazi, GO Schott-Lerner, C Shan, PY Shi, DI Watkins, N Vasilakis, SC Weaver |
Antiviral Research | 2017 |
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Maternal-fetal transmission of the zika virus: An intriguing interplay
C Zanluca, L de Noronha, CN dos Santos |
Tissue Barriers | 2017 |
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Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
MR Salick, MF Wells, K Eggan, A Kaykas |
Journal of visualized experiments : JoVE | 2017 |
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Zika virus infection of Hofbauer cells
MK Simoni, KA Jurado, VM Abrahams, E Fikrig, S Guller |
American Journal of Reproductive Immunology | 2016 |
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Zika: concerns and reality
A Cassone |
Pathogens and Global Health | 2016 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
