ResearchIn-Press PreviewCell biologyDermatology
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10.1172/jci.insight.193017
USP16 drives psoriasis progression by deubiquitinating and stabilizing NLRP3 in keratinocytes
Nan Wang,1 Fangqian Guan,1 Yifan Lin,1 Bohao Sun,2 Jindan Dai,1 Xiejun Xu,1 Weibo Tang,1 Yanhua Ren,3 Xuliang Huang,4 Wenjie Gao,1 Xixi Chen,1 Litai Jin,1 Weitao Cong,1 and Zhongxin Zhu1
1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Find articles by Wang, N. in: PubMed | Google Scholar
1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Find articles by Ren, Y. in: PubMed | Google Scholar
1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Find articles by Jin, L. in: PubMed | Google Scholar
1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
2Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China
4Department of Anaesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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Published January 27, 2026 - More info
Copyright © 2026, Wang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
