ResearchIn-Press PreviewCardiologyCell biology
Open Access | 
10.1172/jci.insight.190760
Phosphoproteomics Identification of ERK-Dependent Activation of Rps6kb1 in Cardiac Hypertrophy
Chao Li,1 Pengfei Zhang,2 Kai Zhang,2 Jane A. Cook,1 Weidan Song,1 Megan Virostek,3 Lily A. Slotabec,4 Nadiyeh Rouhi,4 Mohammed Hazari,3 Michael I. Adenawoola,4 Xiaofei Liu,5 Hao Zhang,5 Guangyu Zhang,1 Erica L Niewold,1 Qinfeng Li,1 Yong Fang,1 Waleed M. Elhelaly,1 Xue-Nan Sun,3 Xuejiang Guo,5 Andrew Lemoff,6 Yingfeng Deng,2 Thomas G. Gillette,1 Ji Li,4 Philipp E. Scherer,3 and Zhao V. Wang2
1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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Scherer, P.
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1Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, United States of America
3Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, United States of America
5State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
6Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, United States of America
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Published January 8, 2026 - More info
Copyright © 2026, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
