Resource and Technical AdvanceIn-Press PreviewDermatologyImmunologyInflammation
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10.1172/jci.insight.185380
An oral lichen planus-like mouse model driven by IFN-γ signaling and cytotoxic CD8+ T cells
Zhenlai Zhu,1 Tinglan Yang,1 Peng Peng,2 Kang Li,3 Wen Qin,1 Chen Zhang,3 Shuyan Wang,1 Yuanyuan Wang,1 Minghui Wei,1 Erle Dang,3 Meng Fu,3 Hao Guo,2 Wen Yin,5 Shuai Shao,3 and Qing Liu1
1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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Zhu, Z.
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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Dang, E.
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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1Department of Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an, China
2Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
4Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
5Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
6Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China
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Published December 11, 2025 - More info
Copyright © 2025, Zhu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
