ResearchIn-Press Preview Open Access | 10.1172/jci.insight.181906
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Xiao, Y. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Hu, Y. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Gao, Y. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Wang, L. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Zhang, L. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Ma, Q. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Ning, Z. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Yu, L. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Li, H. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Liu, J. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Wang, J. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Yang, Y. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Xiong, H. in: JCI | PubMed | Google Scholar
1Cheeloo College of Medicine, Shandong University, Jinan, China
2Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China
3Department of Rheumatology, Affiliated Hospital of Jining Medical University, Jining, China
4Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China
Find articles by Dong, G. in: JCI | PubMed | Google Scholar
Published August 8, 2024 - More info
The interleukin-17 (IL-17) family of cytokines has emerged as a critical player in autoimmune disease, including systemic lupus erythematosus (SLE). However, the role of IL-17B, a poorly understood cytokine, in the pathogenesis of SLE is still not clear. In this study, we investigated the role of IL-17B in the activation and differentiation of B cells, and the pathogenesis of SLE. Intriguingly, IL-17B deficiency aggravated disease in lupus-prone mice and promoted the activation of B cells and the differentiation of germinal center (GC) B cells and plasma cells, while recombinant mouse IL-17B (rmIL-17B) significantly alleviated disease in lupus-prone mice. Mechanistically, rmIL-17B inhibited the activation of the Toll-like receptor (TLR) and interferon (IFN) pathways in B cells by downregulating the FASN-mediated lipid metabolism. Loss of FASN significantly alleviated the disease in lupus-prone mice and inhibited the activation and differentiation of B cells. In addition, B cells had greater FASN expression and lower IL-17RB levels in patients with SLE than in healthy controls. Our study described the role of IL-17B in regulating B-cell activation and differentiation, and alleviating the onset of SLE. These findings will lay a theoretical foundation for further understanding of the pathogenesis of SLE.