TSLP, IL-33, and IL-25: Not just for allergy and helminth infection
The release of cytokines from epithelial and stromal cells is critical for the initiation and
maintenance of tissue immunity. Three such cytokines, thymic stromal lymphopoietin, IL-33,
and IL-25, are important regulators of type 2 immune responses triggered by parasitic worms
and allergens. In particular, these cytokines activate group 2 innate lymphoid cells, TH 2
cells, and myeloid cells, which drive hallmarks of type 2 immunity. However, emerging data
indicate that these tissue-associated cytokines are not only involved in canonical type 2 …
maintenance of tissue immunity. Three such cytokines, thymic stromal lymphopoietin, IL-33,
and IL-25, are important regulators of type 2 immune responses triggered by parasitic worms
and allergens. In particular, these cytokines activate group 2 innate lymphoid cells, TH 2
cells, and myeloid cells, which drive hallmarks of type 2 immunity. However, emerging data
indicate that these tissue-associated cytokines are not only involved in canonical type 2 …
