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The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis

Camilla Tondello,¹ Christine Bender,¹ Gregory J. Golden,² Deborah Puppe,¹ Elisa Blickberndt,¹ Monika Bayer,¹ Giulia K. Buchmann,³ Josef Pfeilschifter,¹ Malte Bachmann,¹ Edith Hintermann,¹ Ralf P. Brandes,³ Michael R. Betts,² Richard A. Kroczek,⁴ and Urs Christen¹

Published February 27, 2025 - More info

Type 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including antigen-presenting cells and islet autoantigen-specific T cells. We have previously generated a roadmap of gene expression in the islet microenvironment during T1D in a mouse model and found that most of the chemokine axes are chronically upregulated during T1D. The XCL1/XCR1 chemokine axis is of particular interest, since XCR1 is exclusively expressed on conventional dendritic cells type 1 (cDC1) that excel by their high capacity for T cell activation. Here we demonstrate cDC1 expressing XCR1 are present in and around the islets of patients with T1D and of islet-autoantibody positive individuals. Further, we show that XCL1 plays an important role in the attraction of highly potent dendritic cells expressing XCR1 to the islets in an inducible mouse model for T1D. XCL1-deficient mice display a diminished infiltration of XCR1+ cDC1 and subsequently a reduced magnitude and activity of islet autoantigen-specific T cells resulting in a profound decrease in T1D incidence. Interference with the XCL1/XCR1 chemokine axis might constitute a novel therapy for T1D.

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