Retraction
Open Access | 
10.1172/jci.insight.173086
Reverse electrical remodeling in rats with heart failure and preserved ejection fraction
Jae Hyung Cho, Peter J. Kilfoil, Rui Zhang, Ryan E. Solymani, Catherine Bresee, Elliot M. Kang, Kristin Luther, Russell G. Rogers, Geoffrey de Couto, Joshua I. Goldhaber, Eduardo Marbán, and Eugenio Cingolani
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Published July 10, 2023 - More info
JCI Insight. 2023;8(13):e173086. https://doi.org/10.1172/jci.insight.173086.
© 2023 Cho et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Abstract
Sudden death is the most common mode of exodus in patients with heart failure and preserved ejection fraction (HFpEF). Cardiosphere-derived cells (CDCs) reduce inflammation and fibrosis in a rat model of HFpEF, improving diastolic function and prolonging survival. We tested the hypothesis that CDCs decrease ventricular arrhythmias (VAs) and thereby possibly contribute to prolonged survival. Dahl salt-sensitive rats were fed a high-salt diet to induce HFpEF. Allogeneic rat CDCs (or phosphate-buffered saline as placebo) were injected in rats with echo-verified HFpEF. CDC-injected HFpEF rats were less prone to VA induction by programmed electrical stimulation. Action potential duration (APD) was shortened, and APD homogeneity was increased by CDC injection. Transient outward potassium current density was upregulated in cardiomyocytes from CDC rats relative to placebo, as were the underlying transcript (Kcnd3) and protein (Kv4.3) levels. Fibrosis was attenuated in CDC-treated hearts, and survival was increased. Sudden death risk also trended down, albeit nonsignificantly. CDC therapy decreased VA in HFpEF rats by shortening APD, improving APD homogeneity, and decreasing fibrosis. Unlike other stem/progenitor cells, which often exacerbate arrhythmias, CDCs reverse electrical remodeling and suppress arrhythmogenesis in HFpEF.
Authors
Jae Hyung Cho, Peter J. Kilfoil, Rui Zhang, Ryan E. Solymani, Catherine Bresee, Elliot M. Kang, Kristin Luther, Russell G. Rogers, Geoffrey de Couto, Joshua I. Goldhaber, Eduardo Marbán, Eugenio Cingolani
Original citation JCI Insight. 2018;3(19):e121123. https://doi.org/10.1172/jci.insight.121123
Citation for this retraction: JCI Insight. 2023;8(13):e173086. https://doi.org/10.1172/jci.insight.173086
The Smidt Heart Institute of Cedars-Sinai Medical Center recently notified JCI Insight of data misrepresentation in this article, discovered in the process of internal review. In particular, natural history controls without surgical intervention were admixed with data from rats randomized to receive surgical placebo infusion, without correct attribution. The authors have indicated that the conclusions of the article may be valid; however, the corresponding author and the institution deemed the data misrepresentation sufficiently substantive to request retraction. Therefore, JCI Insight is retracting this article.
