ResearchIn-Press PreviewImmunologyInfectious disease
Open Access | 10.1172/jci.insight.171605
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Huang, F. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
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Lin, Y.
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1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Qiao, Y. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Yuan, Y. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Zhong, Z. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Luo, B. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Wu, Y. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Liu, J. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Chen, J. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Zhang, W. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Zhang, H. in: JCI | PubMed | Google Scholar
1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Gungzhou, China
3The first Clinical Medical College, Southern Medical University, Guangzhou, China
4Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
5Infectious Diseases Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China
Find articles by Liu, B. in: JCI | PubMed | Google Scholar
Published July 2, 2024 - More info
Upon infection, naïve CD8+ T cells differentiate into cytotoxic effector cells to eliminate the pathogen-infected cells. Although many mechanisms underlying this process have been demonstrated, the regulatory role of chromatin remodel system in this process remains largely unknown. Here we showed that BRD7, a component of the polybromo-associated BRG1-associated factor complex (PBAF), was required for naïve CD8+ T cells to differentiate into functional short-lived effector cells (SLECs) in response to acute infections caused by influenza virus or lymphocytic choriomeningitis virus (LCMV). BRD7-deficiency in CD8+ T cells resulted in profound defects in effector population and functions, thereby impairing viral clearance and host recovery. Further mechanical studies indicated that the expression of BRD7 significantly turned to high from naïve CD8+ T cells to effector cells, bridged BRG1 and PBRM1 to the core module of PBAF complex, consequently facilitating the assembly of PBAF complex rather than BAF complex in the effector cells. The PBAF complex changed the chromatin accessibility at the loci of Tbx21 gene and up-regulated its expression, leading to the maturation of effector T cells. Our research confirms BRD7 and the PBAF complex are key in CD8+ T cell development and present a significant target for advancing immune therapies.