ResearchIn-Press PreviewInflammationMetabolism Open Access | 10.1172/jci.insight.169481
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Zhang, T. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Chen, S. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Li, L. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Jin, Y. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Liu, S. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Liu, Z. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Shi, F. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Xie, L. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Guo, P. in: JCI | PubMed | Google Scholar |
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Cannon, A. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Ergashev, A. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Yao, H. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Huang, C. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Zhang, B. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Wu, L. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Sun, H. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Chen, S. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Shan, Y. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Yu, Z. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Tolosa, E. in: JCI | PubMed | Google Scholar |
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Liu, J. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Fernandez-Zapico, M. in: JCI | PubMed | Google Scholar
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Ma, F. in: JCI | PubMed | Google Scholar |
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
3State Key Laboratory of Pharmaceutical Biotechnology and MOE key laboratory, Model Animal Research Center of Nanjing University, Nanjing, China
4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America
5Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Tajikistan
6CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
7State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key L, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
8Schulze Center for Novel Therapeutics, Division of Oncology Research, Depar, Mayo Clinic, Rochester, United States of America
Find articles by Chen, G. in: JCI | PubMed | Google Scholar
Published May 23, 2024 - More info
Acute Pancreatitis (AP) is among the most common hospital gastrointestinal diagnosis; understanding the mechanisms underlying the severity of AP are critical for development of new treatment options for this disease. Here, we evaluate the biological function of phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) in AP pathogenesis in two independent genetically engineered mouse models of AP. PFKFB3 is elevated in AP and severe AP (SAP) and knockout of Pfkfb3 abrogates the severity of alcoholic SAP (FAEE-SAP). Using a combination of genetic, pharmacological, and molecular studies we define the interaction of PFKFB3 with inositol 1,4,5-trisphosphate receptor (IP3R) as a key event mediating this phenomenon. Further analysis demonstrated that the interaction between PFKFB3 and IP3R promotes FAEE-SAP severity by altering intracellular calcium homeostasis in acinar cells. Together our results support a PFKFB3-driven mechanism controlling AP pathobiology and define this enzyme as a therapeutic target to ameliorate the severity of this dismal condition.