Research ArticleImmunologyTransplantation
Open Access | 
10.1172/jci.insight.168911
Eosinophils restrain humoral alloimmunity after lung transplantation
Zhongcheng Mei,1 May A. Khalil,1 Yizhan Guo,1 Dongge Li,1 Anirban Banerjee,1 Yuriko Terada,2 Yuhei Yokoyama,2 Christina Kratzmeier,1 Kelly Chen,1 Lushen Li,1 Christine L. Lau,1 Jean-Paul Courneya,3 Irina G. Luzina,3 Sergei P. Atamas,3 Andrew E. Gelman,2,4 Daniel Kreisel,2,4 Elizabeth A. Jacobsen,5 and Alexander S. Krupnick1,6
1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
3Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
4Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
5Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Address correspondence to: Alexander Sasha Krupnick, University of Maryland, 29 South Greene Street, Suite 504, Baltimore, Maryland 21201, USA. Phone: 410.328.6366; Email: AKrupnick@som.umaryland.edu.
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Published February 8, 2024 - More info
JCI Insight. 2024;9(3):e168911. https://doi.org/10.1172/jci.insight.168911.
© 2024 Mei et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Received: January 17, 2023; Accepted: December 27, 2023
