ResearchIn-Press PreviewGeneticsNephrology
Open Access | 
10.1172/jci.insight.166470
Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption
Ikhui Kho,1 Ekaterina P. Demina,2 Xuefang Pan,2 Irene Londono,2 Christopher W. Cairo,3 Luisa Sturiale,4 Angelo Palmigiano,5 Angela Messina,5 Domenico Garozzo,4 Roth-Visal Ung,6 Fabrice Mac‐Way,6 Éric Bonneil,7 Pierre Thibault,7 Mathieu Lemaire,8 Carlos R. Morales,1 and Alexey V. Pshezhetsky2
1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Londono, I.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Cairo, C.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Sturiale, L.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Messina, A.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Garozzo, D.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Mac‐Way, F.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Bonneil, É.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Lemaire, M.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Morales, C.
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1Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
2Research Centre, CHU Sainte-Justine, University of Montreal, Montreal, Canada
3Department of Chemistry, University of Alberta, Edmonton, Canada
4CNR, Institute for Polymers, Composites and Biomaterials, IPCB, 95126 Catan, CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
5CNR, Institute for Polymers, Composites and Biomaterials, Catania, Italy
6Department of Medicine, CHU de Québec Research Center, Quebec, Canada
7IRIC, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Canada
8Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
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Pshezhetsky, A.
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Published September 12, 2023 - More info
Copyright © 2023, Kho et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
