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Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea
Seok-Min Yun, … , Joo-Yeon Lee, Young Ki Choi
Seok-Min Yun, … , Joo-Yeon Lee, Young Ki Choi
Published December 26, 2019
Citation Information: JCI Insight. 2020;5(2):e129531. https://doi.org/10.1172/jci.insight.129531.
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Research Article Infectious disease Virology

Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea

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Abstract

To investigate nationwide severe fever with thrombocytopenia syndrome virus (SFTSV) infection status, we isolated SFTSVs from patients with suspected severe fever with thrombocytopenia syndrome (SFTS) in 207 hospitals throughout South Korea between 2013 and April 2017. A total of 116 SFTSVs were isolated from 3137 SFTS-suspected patients, with an overall 21.6% case fatality rate. Genetic characterization revealed that at least 6 genotypes of SFTSVs were co-circulating in South Korea, with multiple reassortments among them. Of these, the genotype B-2 strains were the most prevalent, followed by the A and F genotypes. Clinical and epidemiologic investigations revealed that genotype B strains were associated with the highest case fatality rate, while genotype A caused only one fatality among 10 patients. Further, ferret infection studies demonstrated varying clinical manifestations and case mortality rates with different strains of SFTSV, which suggests this virus could exhibit genotype-dependent pathogenicity.

Authors

Seok-Min Yun, Su-Jin Park, Young-Il Kim, Sun-Whan Park, Min-Ah Yu, Hyeok-Il Kwon, Eun-Ha Kim, Kwang-Min Yu, Hye Won Jeong, Jungsang Ryou, Won-Ja Lee, Youngmee Jee, Joo-Yeon Lee, Young Ki Choi

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Figure 5

Pathogenicity of each randomly selected SFTSV pure genotype (A, B-1, B-2) in ferrets.

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Pathogenicity of each randomly selected SFTSV pure genotype (A, B-1, B-2...
Young adult (<2 years, n = 5; blue) or aged female and male ferrets (>4 years, n = 5; red) were inoculated with 105.0 FFU/mL of each randomly selected SFTSV strain (A) A, (B) B-1, and (C) B-2. Survival, viral titers in serum, and platelet concentration were assessed. The normal range of platelets (171.7 × 103/μL to 1280.6 × 103/μL) is marked by dashed lines in each panel. Both viral titers and platelet concentrations are presented as mean ± SEM. Pound sign (#) indicates no sample due to death of all ferrets of this group. Asterisks (*) indicate statistically significant difference between infected young adult and infected aged ferrets per dpi as determined by the Mantel-Cox method (survival) or 2-way ANOVA with Šidák’s comparison (viral copy number and platelets). Crosses (†) indicate significant difference in platelet count between noninfected aged adult and infected aged ferret as calculated by 2-way ANOVA with Tukey’s test. *P < 0.05, †P < 0.05, ††P < 0.001, ***P < 0.0001.

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