Published November 16, 2017 - More info
Esophageal squamous cell carcinoma (ESCC) is endemic in regions of sub-Saharan Africa (SSA), where it is the third most common cancer. Here, we describe whole-exome tumor/normal sequencing and RNA transcriptomic analysis of 59 patients with ESCC in Malawi. We observed similar genetic aberrations as reported in Asian and North American cohorts, including mutations of
Wenjin Liu, Jeff M. Snell, William R. Jeck, Katherine A. Hoadley, Matthew D. Wilkerson, Joel S. Parker, Nirali Patel, Yohannie B. Mlombe, Gift Mulima, N. George Liomba, Lindsey L. Wolf, Carol G. Shores, Satish Gopal, Norman E. Sharpless
Original citation: JCI Insight. 2016;1(16):e88755. https://doi.org/10.1172/jci.insight.88755
Citation for this addendum: JCI Insight. 2017;2(22):e95978. https://doi.org/10.1172/jci.insight.98457
Whole exome sequencing and RNA sequencing data for this study have been deposited in the NCBI’s Database of Genotypes and Phenotypes (dbGaP phs001448.v1.p1).
See the related article at Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.